ArticleResearch square2025
Spatial transcriptomics reveals distinct cell type dynamics following opioid dependence in mice with the common human variant in the μ-opioid receptor,
Yihan Xie, Omar Guessoum, Johnathan Schug, Adrienne Jo, D Kacy Cullen, Klaus H Kaestner, Julie A Blendy
Abstract readPreprint
In one paragraphArticle in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors.
Yihan XieDepartment of System Pharmacology and Translational Therapeutics, School of Engineering and Applied Science, University of Pennsylvania.ORCID 0009-0002-3084-3204 Omar GuessoumDepartment of Genetics, School of Engineering and Applied Science, University of Pennsylvania.
Johnathan SchugDepartment of Genetics, School of Engineering and Applied Science, University of Pennsylvania.
Adrienne JoDepartment of System Pharmacology and Translational Therapeutics, School of Engineering and Applied Science, University of Pennsylvania.
D Kacy CullenDepartment of Neurosurgery, Perelman School of Medicine, School of Engineering and Applied Science, University of Pennsylvania.ORCID 0000-0002-5355-5216 Klaus H KaestnerDepartment of Genetics, School of Engineering and Applied Science, University of Pennsylvania.
Julie A BlendyDepartment of System Pharmacology and Translational Therapeutics, School of Engineering and Applied Science, University of Pennsylvania.ORCID 0000-0003-1705-9001 Funding
TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GARY D. WU · 1997 to 2026
$32.5MCircuitry dynamics underlying opioid-dependence: Integrating structural, functional, and transcriptomic mechanismsR01DA056599 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI KEVIN T BEIER, Julie A Blendy · 2022 to 2026
$3.8MMapping opioid-dependence state transitions across structural, functional, and transcriptomic topologiesR01DA054374 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A, CORDER, GREGORY · 2021 to 2025
$2.4MNIDA NIH HHS R01 DA054374NIDA NIH HHS R01 DA056599NIDDK NIH HHS P30 DK050306
6 · The paper itselfAbstract
Opioid Use Disorder (OUD) is a multifaceted neuropsychiatric disease that can arise from genetic, environmental, and neurobiological factors. The
Identifiers
PMID40894067
PMCPMC12393594
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390