ArticleResearch square2025
Multi-ancestry Genome-wide Association Study of Inpatient Opioid Dosing Following Knee or Hip Arthroplasty.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Opioids are commonly prescribed to manage acute postoperative pain. However, individuals vary in their opioid dosing needs, with no validated biomarkers to guide prescribing. We used electronic health records (EHR) data from the Million Veteran Program sample to investigate individual differences in opioid analgesic dosing following knee (n=18,540) or hip (n=9,363) arthroplasty. We extracted data from pharmacy records on inpatient opioid medications to estimate average daily morphine milligram equivalent (MME) dosages and used genome-wide association studies (GWAS) to identify genetic variants associated with daily MME dosage, followed by a cross-ancestry and cross-phenotype meta-analysis. We identified two genome-wide significant loci in the African ancestry knee arthroplasty GWAS and three in the Admixed-American ancestry hip arthroplasty GWAS. Multiple other loci in African, Admixed-American, and European populations were nominally significant. The study provides a framework for the use of EHR data to examine the genetics of opioid dosing in post-operative care.
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Registered trials
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