Evidence map›Paper›PMID 40894037›Full record

ArticleResearch square2025

Defensive tolerance drives the reprogramming and dysfunction of infiltrating pathogenic B cells assuring the maintenance of tolerance.

Koki Hayashi, Takahiro Yokose, Jenna Lancey, Edward S Szuter, Brandon Kwon, Fabian Murillo, Alessia Giarraputo, Ivy Rosales, Wenjun Li, Michael T Guinn and 23 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Koki HayashiCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School; Boston, MA, USA.
Takahiro YokoseCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School; Boston, MA, USA.
Jenna LanceyCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School; Boston, MA, USA.
Edward S SzuterCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School; Boston, MA, USA.
Brandon KwonCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School; Boston, MA, USA.ORCID 0009-0006-2053-3770
Fabian MurilloCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School; Boston, MA, USA.
Alessia GiarraputoDepartment of Pathology, Massachusetts General Hospital; Boston, MA, USA.
Ivy RosalesCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School; Boston, MA, USA.ORCID 0000-0003-0621-3202
Wenjun LiDepartments of Surgery, Pathology, and Immunology, Washington University in St. Louis, St. Louis, MO.
Michael T GuinnCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School; Boston, MA, USA.
Grant CosimiCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School; Boston, MA, USA.
Sarah Rose OdutolaCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School; Boston, MA, USA.
Joylyn KimCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School; Boston, MA, USA.
Peter T SageTransplantation Research Center, Brigham and Women's Hospital and Harvard Medical School; Boston, MA, USA.ORCID 0000-0002-7287-0326
Giuseppe TarantinoDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, and Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-6078-6856
Amy HuangDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, and Broad Institute of MIT and Harvard, Cambridge, MA, USA.
David LiuDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, and Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-0346-5033
Derek EffiomMassachusetts General Hospital Cancer Center, Boston, MA, USA.
Genevieve M BolandMassachusetts General Hospital Cancer Center, Boston, MA, USA.ORCID 0000-0002-7522-6173
Sonia CohenMassachusetts General Hospital Cancer Center, Boston, MA, USA.
Oliver McCallionNuffield Department of Surgical Sciences, University of Oxford, United Kingdom.
Fadi IssaNuffield Department of Surgical Sciences, University of Oxford, United Kingdom.ORCID 0000-0002-8279-7732
Collin JordanDepartment of Medicine, Duke University, Durham, North Carolina, USA.ORCID 0009-0008-7027-7319
Xunrong LuoDepartment of Medicine, Duke University, Durham, North Carolina, USA.ORCID 0000-0001-5581-9409
Andrew S LissDepartment of Surgery, Massachusetts General Hospital and Harvard Medical School; Boston, MA, USA.
David A RuddyNovartis Biomedical Research, Oncology, Cambridge, Massachusetts, USA.
Michelle PiquetNovartis Biomedical Research, Oncology, Cambridge, Massachusetts, USA.
Paul S RussellCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School; Boston, MA, USA.
Robert B ColvinCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School; Boston, MA, USA.
Joren C MadsenCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School; Boston, MA, USA.
A Benedict CosimiCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School; Boston, MA, USA.
Daniel KreiselDepartments of Surgery, Pathology, and Immunology, Washington University in St. Louis, St. Louis, MO.
Alessandro AlessandriniCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School; Boston, MA, USA.

Funding

The Role of Neutrophils in Regulating Lung Transplant ToleranceP01AI116501 · NIAID · WASHINGTON UNIVERSITY · PI ALEXANDER S. KRUPNICK · 2015 to 2026
$19.4M
Project 3: The Role of Erythropoietin in Kidney Transplant ToleranceP01AI123086 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI COLVIN, ROBERT B · 2016 to 2020
$10.6M
THE ROLE OF ISCHEMIA REPERFUSION INJURY IN LUNG ALLOGRAFT REJECTIONR01HL094601 · NHLBI · WASHINGTON UNIVERSITY · PI Andrew Eric Gelman, Daniel Kreisel · 2009 to 2026
$6.9M
Donor Kidney Resident Macrophages in Kidney Allograft Early Inflammation and AlloimmunityR01DK132889 · NIDDK · DUKE UNIVERSITY · PI Irma Husain · 2022 to 2026
$2.4M
BLRD VA I01 BX002730NHLBI NIH HHS R01 HL094601NIAID NIH HHS P01 AI116501NIAID NIH HHS P01 AI123086NIDDK NIH HHS R01 DK132889
6 · The paper itself

Abstract

We previously showed that infiltrating cytotoxic immune cells are reprogrammed to regulatory-like/exhausted cells within accepted kidney allografts through a 'defensive tolerance' mechanism. We observed a regulatory B cell (Breg) signature within the accepted kidney. Here we show that despite a Breg phenotype, neither B cell depletion nor the use of μMT recipients which lack B cells, resulted in kidney allograft rejection. Negative regulators of B cell function,

Identifiers

PMID40894037
PMCPMC12393600

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.