Evidence map›Paper›PMID 40894031›Full record

ArticleResearch square2025

Obesogenic effects of warm temperature involve feeding adaptation by preoptic area leptin receptor neurons.

Laura Kaiser, Nathan Lee, Jaclyn Williams, Michael Smith, Robert C Noland, Sangho Yu, Christopher D Morrison, Hans-Rudolf Berthoud, Heike Münzberg

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Laura KaiserNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU system, Baton Rouge, LA, USA.ORCID 0000-0002-4971-0586
Nathan LeeNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU system, Baton Rouge, LA, USA.
Jaclyn WilliamsNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU system, Baton Rouge, LA, USA.
Michael SmithNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU system, Baton Rouge, LA, USA.
Robert C NolandNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU system, Baton Rouge, LA, USA.ORCID 0000-0001-5543-3450
Sangho YuNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU system, Baton Rouge, LA, USA.ORCID 0000-0002-2973-7562
Christopher D MorrisonNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU system, Baton Rouge, LA, USA.ORCID 0000-0002-5492-102X
Hans-Rudolf BerthoudNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU system, Baton Rouge, LA, USA.ORCID 0000-0003-0787-1709
Heike MünzbergNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU system, Baton Rouge, LA, USA.ORCID 0000-0002-1152-4884

Funding

Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI ROBERT A KESTERSON · 2005 to 2026
$26.5M
THE ROLE OF PROTEIN MALNUTRITION ON CIRCADIAN PHYSIOLOGY OF C57BL/6J MOUSE DAMSP20RR021945 · NCRR · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI GETTYS, THOMAS W · 2006 to 2011
$9.5M
CENTER FOR NEUROANATOMY WITH NEUROTROPIC VIRUSES: COMPARATIVE MEDICINEP40RR018604 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRICK, PETER · 2004 to 2011
$6.5M
Leptin and Central Control of ThermoregulationR01DK092587 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MUENZBERG-GRUENING, HEIKE · 2012 to 2024
$3.5M
Genetically-based neuro-modulation of adipose tissue functionsOT2OD023864 · OD · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MUENZBERG-GRUENING, HEIKE · 2016 to 2019
$3.1M
Metabolic Changes: Connecting temperature sensing neurons to sympathetic adipose tissue stimulationR01AT011683 · NCCIH · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MUENZBERG-GRUENING, HEIKE · 2021 to 2025
$2.5M
Sable Systems Promethion for Mouse Metabolic AnalysisS10OD023703 · OD · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MORRISON, CHRISTOPHER D · 2017 to 2017
$626k
NCCIH NIH HHS R01 AT011683NCRR NIH HHS P20 RR021945NCRR NIH HHS P40 RR018604NIDDK NIH HHS P30 DK072476NIDDK NIH HHS R01 DK092587NIH HHS OT2 OD023864NIH HHS S10 OD023703
6 · The paper itself

Abstract

The preoptic area (POA) is a well-established regulator of body temperature, but its role in feeding behavior remains underexplored. Our study identifies leptin receptor (Lepr)-expressing neurons in the POA (POA

Indexed as

energy-statefastingmeal patternmelanocortin-4-receptorsatiety

Identifiers

PMID40894031
PMCPMC12393463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.