ArticleResearch square2025
Sensitive dLight3 for imaging broad-spectrum dopamine events across brain regions.
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In one paragraph
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors.
Jacob I RoshgadolMax Planck Florida Institute for Neuroscience, Jupiter, FL, USA.ORCID https://orcid.org/0000-0003-3541-0715
Julie A ChouinardMax Planck Florida Institute for Neuroscience, Jupiter, FL, USA.ORCID https://orcid.org/0000-0003-1266-3111
Shouvik MajumderMax Planck Florida Institute for Neuroscience, Jupiter, FL, USA.
Erin C ScottMax Planck Florida Institute for Neuroscience, Jupiter, FL, USA.ORCID https://orcid.org/0000-0002-9715-1512
Katharine BorgesDepartment of Neuroscience, University of California Berkeley, Berkeley, CA.
Kenta M HagiharaAllen Institute for Neural Dynamics, Seattle, WA, USA.ORCID https://orcid.org/0000-0003-0064-0852
Nino ManciniMax Planck Florida Institute for Neuroscience, Jupiter, FL, USA.ORCID https://orcid.org/0000-0002-3455-7101
Tanner StevesonNeuroscience Graduate Group, Center for Neuroscience, University of California Davis, Davis, CA.
Tarun KamathDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Bart LodderDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0009-0001-1733-1311
Bryan J MacLennanAllen Institute for Neural Dynamics, Seattle, WA, USA.
Rochelin DalanginDepartment of Biochemistry and Molecular Medicine, University of California Davis, Davis, CA, USA.ORCID https://orcid.org/0000-0002-1914-507X
Nikki TjahjonoMax Planck Florida Institute for Neuroscience, Jupiter, FL, USA.
Akash PalMax Planck Florida Institute for Neuroscience, Jupiter, FL, USA.
Carina Soares-CunhaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.ORCID https://orcid.org/0000-0001-9470-644X
Patrick R MeluginDepartment of Pharmacology, Vanderbilt Brain Institute, Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN, USA.
Aaron MarleyDepartment of Psychiatry, University of California San Francisco, San Francisco, CA, USA.
Karan MaheDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Kiyoto KurimaOkinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
Sakiko TakahashiOkinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
Dvyne NosakaOkinawa Institute of Science and Technology Graduate University, Okinawa, Japan.ORCID https://orcid.org/0009-0001-3495-8589
Kazuma MurakamiMax Planck Florida Institute for Neuroscience, Jupiter, FL, USA.
Lesley A ColganMax Planck Florida Institute for Neuroscience, Jupiter, FL, USA.ORCID https://orcid.org/0000-0003-2089-6820
Peter T FreitasDepartment of Biochemistry and Molecular Medicine, University of California Davis, Davis, CA, USA.ORCID https://orcid.org/0000-0003-1351-8186
Rishidev ChaudhuriCenter for Neuroscience & Department of Neurology, University of California Davis, Davis, CA.ORCID https://orcid.org/0000-0003-2301-3261
Cody A SicilianoDepartment of Psychiatry, University of California San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0001-9871-2089
Ana João RodriguesDepartment of Pharmacology, Vanderbilt Brain Institute, Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN, USA.ORCID https://orcid.org/0000-0003-1968-7968
Viviana GradinaruDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID https://orcid.org/0000-0001-5868-348X
Mark Von ZastrowDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Kaspar PodgorskiDepartment of Neuroscience, University of California Berkeley, Berkeley, CA.
Bernardo L SabatiniDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0003-0095-9177
Salil S BidayeMax Planck Florida Institute for Neuroscience, Jupiter, FL, USA.ORCID https://orcid.org/0000-0001-9494-6531
Timothy D HanksCenter for Neuroscience & Department of Neurology, University of California Davis, Davis, CA.ORCID https://orcid.org/0000-0003-4147-4475
Na JiDepartment of Neuroscience, University of California Berkeley, Berkeley, CA.ORCID https://orcid.org/0000-0002-5527-1663
Jeffery R WickensOkinawa Institute of Science and Technology Graduate University, Okinawa, Japan.ORCID https://orcid.org/0000-0002-8795-1209
Hidehiko K InagakiMax Planck Florida Institute for Neuroscience, Jupiter, FL, USA.ORCID https://orcid.org/0000-0003-4580-2763
Lin TianMax Planck Florida Institute for Neuroscience, Jupiter, FL, USA.ORCID https://orcid.org/0000-0001-7012-6926
Funding
Novel Genetically Encoded Indicators for Interrogating Neuron-Astrocyte Communication Across TimescalesU19NS123719 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EROGLU, CAGLA · 2021 to 2025
$10.7MPROTEINS REGULATING ENDOCYTOSIS OF OPIOID RECEPTORSR01DA012864 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mark E Von Zastrow · 2000 to 2026
$7.9MOptimization of genetically encoded voltage and neurotransmitter indicators for multiwavelength in vivo analysis of brain circuitsUM1MH136462 · NIMH · MAX PLANCK FLORIDA CORPORATION · PI Michael Z. Lin, Kaspar Podgorski · 2024 to 2026
$6.3MEngineered AAV Identification, Validation, and Dissemination Pipeline for Brain Cell Type-Specific Manipulation Across SpeciesUF1MH128336 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI FOX, ANDREW S, GRADINARU, VIVIANA · 2021 to 2021
$6.1MMembrane Trafficking of Opioid and Adrenergic ReceptorsR01DA010711 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VONZASTROW, MARK E · 2014 to 2023
$4.6MMultiplex interrogation of neuromodulatory signaling in behaving animals with enhanced depth and resolutionU01NS120820 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TIAN, LIN, VONZASTROW, MARK E · 2021 to 2024
$3.5MInitiative for Maximizing Student Development at the University of California, Davis.T32GM135741 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ALDRIN V. GOMES, Manuel F Navedo · 2020 to 2026
$3.2MGenetically-Encoded, Non-Invasive and Wireless Modulation of Calcium Dynamics in Astrocytes With Spatiotemporal Precision and DepthR01NS129888 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Chunlei Liu, Lin Tian · 2023 to 2026
$2.9MGenetically encoded indicators for large-scale sensing of neuromodulatory signaling in behaving animalsU01NS103522 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NIMMERJAHN, AXEL, TIAN, LIN · 2017 to 2019
$2.9MAction and Interaction of Neurotransmitters and NeuromodulatorsR35NS137336 · NINDS · HARVARD MEDICAL SCHOOL · PI Bernardo L Sabatini · 2024 to 2026
$2.1MMesocortical neuromodulation in punishment-resistant alcohol drinkingR01AA030115 · NIAAA · VANDERBILT UNIVERSITY · PI Cody Siciliano · 2022 to 2026
$2.1M8/8: INIA Stress and Chronic Alcohol Interactions: Cross-species plasticity signatures of alcohol and stressU01AA029971 · NIAAA · VANDERBILT UNIVERSITY · PI Cody Siciliano · 2022 to 2026
$2.0MNIAAA NIH HHS R01 AA030115NIAAA NIH HHS U01 AA029971NIDA NIH HHS F30 DA061675NIDA NIH HHS F32 DA038913NIDA NIH HHS R01 DA010711NIDA NIH HHS R01 DA012864NIDDK NIH HHS F32 DK112589NIGMS NIH HHS T32 GM135741NIMH NIH HHS F31 MH135696NIMH NIH HHS UF1 MH128336NIMH NIH HHS UM1 MH136462NINDS NIH HHS R01 NS129888NINDS NIH HHS R35 NS137336NINDS NIH HHS U01 NS090604NINDS NIH HHS U01 NS103522NINDS NIH HHS U01 NS120820NINDS NIH HHS U19 NS123719
Abstract
Dopaminergic neurons modulate movement, motivation, and learning by dynamically regulating dopamine release across distributed neural circuits. However, existing genetically encoded dopamine sensors lack the sensitivity and resolution to capture the full amplitude and temporal complexity of
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.