Evidence map›Paper›PMID 40894026›Full record

ArticleResearch square2025

SputOMICs identifies common and distinct markers in cystic fibrosis and chronic obstructive pulmonary disease.

Sebastien Boutin, Dario Frey, Barbara Helm, Matteo Guerra, Matthias Hagner, Junyan Lu, Susanne Dittrich, Sabine Wege, Ralf Eberhardt, Felix Herth and 5 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Sebastien BoutinInstitute of Medical Microbiology, University of Lübeck and University Hospital Schleswig-Holstein, Campus Lübeck.ORCID 0000-0002-0499-2460
Dario FreyGerman Cancer Research Center (DKFZ).ORCID 0000-0001-9572-9686
Barbara HelmGerman Cancer Research Center (DKFZ).
Matteo GuerraDepartment of Translational Pulmonology, University of Heidelberg.
Matthias HagnerDepartment of Translational Pulmonology, University of Heidelberg.
Junyan LuHeidelberg.ORCID 0000-0002-9211-0746
Susanne DittrichThoraxKlinik, University Heidelberg.ORCID 0000-0003-0803-7513
Sabine WegeThoraxKlinik, University Heidelberg.
Ralf EberhardtThoraxKlinik, University Heidelberg.
Felix HerthThoraxklinik, University Hospital Heidelberg.
Olaf SommerburgDivision of Pediatric Pulmonology & Allergology and Cystic Fibrosis Center, Department of Pediatrics, University of Heidelberg.
Carsten SchultzOregon Health and Science University.
Alexander DalpkeUniversity Hospital Heidelberg.
Ursula KlingmuellerGerman Cancer Research Center (DKFZ).
Marcus MallCharité - Universitätsmedizin Berlin.ORCID 0000-0002-4057-2199

Funding

Determining the role of sphingolipids in Mycobacterium tuberculosis infectionR01AI141549 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI TAFESSE, FIKADU G. · 2020 to 2025
$2.4M
Chemical biology tools for studying growth factor receptor internalizationR01GM127631 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SCHULTZ, CARSTEN · 2018 to 2024
$2.4M
NIAID NIH HHS R01 AI141549NIGMS NIH HHS R01 GM127631
6 · The paper itself

Abstract

Cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are muco-obstructive lung diseases. Knowledge of molecular processes has much improved therapeutic options in CF, whereas much less is known for COPD, a disease affecting an increasing number of patients. Here, we report a multilayer workflow integrating microbiome, inflammation and proteome profiling with clinical data to identify disease specific characteristics in sputum. Our proof-of-concept study shows that CF sputum is dominated by

Identifiers

PMID40894026
PMCPMC12393495

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.