ArticleResearch square2025
An interplay of non-coding RNAs regulates
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Authors and funding
31 authors.
Shuangyue LiDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.
Xiaoning SongDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.
Anastasiia DiagelDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.ORCID 0009-0001-4512-9874
Ling LiDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany TUM School of Computation, Information and Technology (CIT), Technical University Munich, 85748 Garching bei München, Germany.
Aldo MoggioDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich.ORCID 0000-0001-6513-5406
Yifan ChenDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.
Zhaolong LiMolecular Vascular Medicine, Klinikum rechts der Isar - Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.
Tan DangDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.ORCID 0009-0005-1770-5765
Miaomiao LiDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.
Rui ShenDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.ORCID 0009-0000-8807-9523
Angela MaDepartment of Genetics and Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai.
Marius SchwabDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich.
Nicolas BarberaCenter for Public Health Genomics, University of Virginia.
Constanze LehertshuberDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.
Amos RomerDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.
Luigi Filippo BrizziDepartment of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padova, Padova, Italy.ORCID 0009-0007-5917-1057
Johannes KreftingDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.ORCID 0000-0002-7755-0954
Nils KrügerDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.
Hendrik SagerDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.ORCID 0000-0002-0197-6553
Reinier BoonGoethe University Hospital, Institute for Cardiovascular Regeneration.ORCID 0000-0001-7944-9748
Mete CivelekCenter for Public Health Genomics, University of Virginia Department of Biomedical Engineering, University of Virginia.
Casey RomanoskiDepartment of Cellular and Molecular Medicine, The University of Arizona.
Aldons LusisDavid Geffen School of Medicine, University of California.ORCID 0000-0001-9013-0228
Andreas SchoberInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität München Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.
Thorsten KesslerDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.ORCID 0000-0003-3326-1621
Moritz von ScheidtDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.ORCID 0000-0001-7159-8271
Johan BjörkegrenDepartment of Medicine, Huddinge, Karolinska Institutet, Karolinska Universitetssjukhuset Department of Genetics and Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai.
Lars MaegdefesselMolecular Vascular Medicine, Klinikum rechts der Isar - Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.ORCID 0000-0001-5228-2634
Maliheh Nazari-JahantighInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität München Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.
Heribert SchunkertDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.ORCID 0000-0001-6428-3001
Zhifen ChenDepartment of Cardiology, German Heart Center, TUM University Hospital, TUM School of Medicine and Health, Technical University Munich Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK), partner site Munich Heart Alliance (MHA), Munich, Germany.
Funding
Systems Genetics Dissection of Non-alcoholic SteatohepatitisR01DK117850 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aldons Jake Lusis · 2019 to 2026
$4.6MEvaluation of anti-fibrotic and anti-inflammatory semi-synthetic oxysterol, Oxy210, as a therapeutic drug candidate for non-alcoholic steatohepatitisR44DK136405 · NIDDK · MAX BIOPHARMA, INC. · PI PARHAMI, FARHAD · 2023 to 2024
$1.8MNIDDK NIH HHS R01 DK117850NIDDK NIH HHS R44 DK136405
Abstract
Many common diseases have a polygenic architecture. The responsible alleles are thought to mediate risk by disturbing gene regulation in most cases, however, the precise mechanisms have been elucidated only for a few. Here, we investigated the
Indexed as
3’ untranslated region (3’ UTR)Coronary artery disease (CAD)CRISPR activation (CRISPRa)CRISPR/Cas9dRfxCas13dGWAS-eQTL colocalization analysislong non-coding RNA (lncRNA)microRNA (miRNA)RNA interferenceRNA stability
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.