Evidence map›Paper›PMID 40894015›Full record

ArticleResearch square2025

Opposing Modulation of EEG Aperiodic Component by Ketamine and Thiopental: Implications for the Noninvasive Assessment of Cortical E/I Balance in Humans.

Jose Cortes-Briones, Juan Urrutia-Gandolfo, Pablo Estevez, Arnab Sengupta, Matthew Basilico, Patrick Skosnik, Diana DeNegre, Deepak D'Souza, Ismene Petrakis, John Krystal

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jose Cortes-BrionesYale University.
Juan Urrutia-GandolfoYale University.
Pablo EstevezUniversidad de Chile.ORCID 0000-0001-9164-4722
Arnab SenguptaYale University.
Matthew BasilicoYale University.
Patrick SkosnikNortheastern University.
Diana DeNegreVA Connecticut Healthcare System.
Deepak D'SouzaYale University.
Ismene PetrakisYale University.
John KrystalYale University.ORCID 0000-0001-6952-1726

Funding

Translational Technologies CoreP50AA012870 · NIAAA · YALE UNIVERSITY · PI John H. Krystal · 2001 to 2026
$43.7M
Translational Neuroscience Research in Alcoholism (TNRA-TP)T32AA015496 · NIAAA · YALE UNIVERSITY · PI PETRAKIS, ISMENE L. · 2005 to 2014
$1.6M
AMINO ACID NEUROTRANSMITTER DYSREGULATION IN ALCOHOLISMK05AA014906 · NIAAA · YALE UNIVERSITY · PI KRYSTAL, JOHN H. · 2004 to 2008
$918k
NIAAA NIH HHS K05 AA014906NIAAA NIH HHS P50 AA012870NIAAA NIH HHS T32 AA015496
6 · The paper itself

Abstract

The balance between excitatory and inhibitory (E/I) activity is critical for brain function, and its disruption is implicated in neuropsychiatric disorders. Electrophysiological signals can be decomposed into periodic (oscillatory) and aperiodic components. In the power spectrum, the periodic component appears as narrowband peaks, while the aperiodic component underlies its characteristic 1/f

Identifiers

PMID40894015
PMCPMC12393595

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.