Evidence map›Paper›PMID 40894004›Full record

ArticleGynecologic oncology reports2025

Take it or leave it? Incidental appendectomy at time of gynecologic oncology laparotomy.

Nora Badiner, Angela Mirzadeh, Lauren Sword, Mary Herberger, Hayley Butler, Ruofan Yao, Yevgeniya Ioffe, Linda Hong

Abstract read
In one paragraph

Article in Gynecologic oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Reconsidering Routine Appendectomy in Ovarian Neoplasms: Implications for Diagnostic Staging.Nigerian medical journal : journal of the Nigeria Medical Association
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nora BadinerLoma Linda University Medical Center, Division of Gynecologic Oncology, Department of Gynecology and Obstetrics, 11175 Campus Street, Coleman Pavilion, Room #11105, Loma Linda, CA 92354, United States.
Angela MirzadehLoma Linda University Medical Center, Department of Gynecology and Obstetrics, 11175 Campus Street, Coleman Pavilion, Room #11105, Loma Linda, CA 92354, United States.
Lauren SwordLoma Linda University Medical Center, Department of Gynecology and Obstetrics, 11175 Campus Street, Coleman Pavilion, Room #11105, Loma Linda, CA 92354, United States.
Mary HerbergerLoma Linda University Medical Center, Department of Gynecology and Obstetrics, 11175 Campus Street, Coleman Pavilion, Room #11105, Loma Linda, CA 92354, United States.
Hayley ButlerLoma Linda University Medical Center, Department of Gynecology and Obstetrics, 11175 Campus Street, Coleman Pavilion, Room #11105, Loma Linda, CA 92354, United States.
Ruofan YaoLoma Linda University Medical Center, Division of Maternal Fetal Medicine, Department of Gynecology and Obstetrics, 11175 Campus Street, Coleman Pavilion, Room #11105, Loma Linda, CA 92354, United States.
Yevgeniya IoffeLoma Linda University Medical Center, Division of Gynecologic Oncology, Department of Gynecology and Obstetrics, 11175 Campus Street, Coleman Pavilion, Room #11105, Loma Linda, CA 92354, United States.
Linda HongLoma Linda University Medical Center, Division of Gynecologic Oncology, Department of Gynecology and Obstetrics, 11175 Campus Street, Coleman Pavilion, Room #11105, Loma Linda, CA 92354, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The role of appendectomy in gynecologic oncology surgery has primarily been studied in mucinous ovarian pathologies. We sought to assess the safety and potential benefits of performing incidental appendectomy at time of exploratory laparotomy performed by gynecologic oncologists. Methods: Retrospective chart review of patients undergoing exploratory laparotomy with the gynecologic oncology division. Exclusion criteria included cesarean hysterectomy and reoperation. Patients were matched on BMI, procedure date and type. 513 patients were identified for inclusion: 169 patients underwent appendectomy and 344 patients did not. Demographic and clinical characteristics were abstracted from the electronic medical record. Appendiceal appearance was confirmed via pathology report. Safety outcomes included length of hospital stay and postoperative complications. Results: The two groups were demographically similar. There was no significant difference in length of hospital stay between the cohorts (6.10 ± 5.34 days vs. 5.87 ± 5.34 days, P = 0.645) and no increased rate of any of the postoperative complications in the appendectomy group. 119 patients (70.4 %) had abnormal appendixes intraoperatively. Among normal appendixes, six (12 %) had an occult finding only diagnosed on final pathology. No patients with apparent pelvic-confined gynecologic cancer were upstaged solely due to metastasis to the appendix. Conclusions: When performed by a gynecologic oncologist, appendectomy at the time of laparotomy was safe and did not increase the risk of complications. Our results demonstrate a high rate of occult abnormal histology despite a normal intraoperative appearance. These findings suggest that intraoperative appearance alone is not sufficient, and support performing incidental appendectomy at the time of gynecologic oncology exploratory laparotomy.

Indexed as

Incidental appendectomyOccult pathologyOptimal cytoreduction

Identifiers

PMID40894004
PMCPMC12396251

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.