Evidence map›Paper›PMID 40893995›Full record

ArticleIEEE transactions on instrumentation and measurement2025

Measuring Subtle HD Data Representation and Multimodal Imaging Phenotype Embedding for Precision Medicine.

Bardia Yousefi, Mélina Khansari, Ryan Trask, Patrick Tallon, Carina Carino, Arman Afrasiyabi, Vikas Kundra, Lan Ma, Lei Ren, Keyvan Farahani and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IEEE transactions on instrumentation and measurement, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bardia YousefiDepartment of Biocomputational Engineering Program, University of Maryland, College Park, MD 20742 USA.ORCID https://orcid.org/0000-0003-3121-7045
Mélina KhansariDepartment of Biocomputational Engineering Program, University of Maryland, College Park, MD 20742 USA.ORCID https://orcid.org/0000-0002-4985-0239
Ryan TraskDepartment of Biocomputational Engineering Program, University of Maryland, College Park, MD 20742 USA.ORCID https://orcid.org/0000-0002-6597-942X
Patrick TallonDepartment of Biocomputational Engineering Program, University of Maryland, College Park, MD 20742 USA.ORCID https://orcid.org/0000-0001-7953-7895
Carina CarinoDepartment of Biocomputational Engineering Program, University of Maryland, College Park, MD 20742 USA.ORCID https://orcid.org/0000-0003-3248-310X
Arman AfrasiyabiYale University, New Haven, CT 06520 USA.ORCID https://orcid.org/0000-0002-7346-3319
Vikas KundraSchool of Medicine, University of Maryland Baltimore, Baltimore, MD 21201 USA.ORCID https://orcid.org/0000-0002-3262-4059
Lan MaDepartment of Biocomputational Engineering Program, University of Maryland, College Park, MD 20742 USA.ORCID https://orcid.org/0000-0001-6404-3649
Lei RenSchool of Medicine, University of Maryland Baltimore, Baltimore, MD 21201 USA.ORCID https://orcid.org/0000-0003-3222-2102
Keyvan FarahaniNational Institute of Health (NIH), Bethesda, MD 20814 USA.ORCID https://orcid.org/0000-0003-2111-1896
Michelle HershmanDepartment of Radiology, Boise Radiology Group, University of Pennsylvania, Philadelphia, PA 19104 USA.ORCID https://orcid.org/0000-0003-1075-1863

Funding

Resource Sharing CoreU54CA273956 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI Phuoc T. Tran · 2022 to 2026
$8.9M
eXtended Modular ANthropomorphic (XMAN) phantom for Imaging and Treatment Optimization in Radiotherapy.R01EB032680 · NIBIB · UNIVERSITY OF MARYLAND BALTIMORE · PI REN, LEI, YANG, XIAOFENG · 2022 to 2025
$2.4M
Study of Biological and Radiographic Biomarkers and Association with Ancestry and Survival Disparities in Oral Cavity Squamous Cell Carcinoma Using AI ApproachesR01DE033426 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI Daria A Gaykalova, Ranee Mehra · 2024 to 2026
$2.0M
3-dimensional prompt gamma imaging for online proton beam dose verificationR01CA279013 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI Jerimy C. Polf, Lei Ren · 2023 to 2026
$1.9M
3D In vivo dosimetry for FLASH proton therapyU01CA288351 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Yong Chen, Lei Ren · 2024 to 2026
$1.8M
NCI NIH HHS R01 CA279013NCI NIH HHS U01 CA288351NCI NIH HHS U54 CA273956NIBIB NIH HHS R01 EB032680NIDCR NIH HHS R01 DE033426
6 · The paper itself

Abstract

High-dimensional (HD) imaging biomarkers offer enhanced imaging characterization, yet their abundance impedes system performance. The methods that embed HD onto lower dimensional (LD) space address this challenge effectively, particularly for multimodal scenarios. In this study, we proposed different embedding approaches to tackle such a problem. The shortest path algorithm for isometric mapping (Isomap) is modified by an additional constraint using the Parzen-Rosenblatt (PR) density function. This aids in maintaining the uniformity of the graphs through HD to LD projections via Isomap. Then, we proposed Gaussian and Kaniadakis entropy-driven,

Indexed as

Distribution embeddingGaussian embeddingisometric mapping (Isomap)Kaniadakis–Gaussian distribution embeddingmultimodal imaging phenotypic embeddingParzen–Rosenblatt (PR) constraint

Identifiers

PMID40893995
PMCPMC12393170

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.