Evidence map›Paper›PMID 40893954›Full record

ArticleACS central science2025

Elevated Toxic Element Emissions from Popular Disposable E‑Cigarettes: Sources, Life Cycle, and Health Risks.

Mark R Salazar, Lalima Saini, Tran B Nguyen, Kent E Pinkerton, Amy K Madl, Austin M Cole, Brett A Poulin

Abstract read
In one paragraph

Article in ACS central science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trends in product characteristics of disposable e-cigarettes sold by US online stores between 2022 and 2024.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Article
  2. Article
  3. Article
  4. Influence of e-Liquid pH on Heavy Metal Emissions in Open-System Electronic Cigarette Aerosols and Associated Health Risks.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mark R SalazarDepartment of Environmental Toxicology, University of California Davis, Davis, California 95616, United States.ORCID https://orcid.org/0009-0006-1297-7144
Lalima SainiDepartment of Environmental Toxicology, University of California Davis, Davis, California 95616, United States.
Tran B NguyenDepartment of Environmental Toxicology, University of California Davis, Davis, California 95616, United States.ORCID https://orcid.org/0000-0001-9206-4359
Kent E PinkertonCenter for Health and the Environment, University of California Davis, Davis, California 95616, United States.
Amy K MadlCenter for Health and the Environment, University of California Davis, Davis, California 95616, United States.
Austin M ColeInterdisciplinary Center for Plasma Mass Spectrometry, University of California Davis, Davis, California 95616, United States.
Brett A PoulinDepartment of Environmental Toxicology, University of California Davis, Davis, California 95616, United States.ORCID https://orcid.org/0000-0002-5555-7733

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapidly evolving market of disposable e-cigarettes poses unknown health risks to adolescents and young adults. We report excessive emissions of toxic metallic elements in aerosols from flavored and "clear" versions of three popular products (Esco Bar, Flum Pebble, and ELF Bar), orders of magnitude higher in concentration than traditional cigarettes and other e-cigarettes. Heating coil elements (chromium (Cr), nickel (Ni)) likely leached into e-liquids and aerosols from coil degradation during use, increasing up to 1000-fold in concentration over the device life. In Esco Bar devices, high concentrations of lead (Pb, ≤175 ppm), Ni (≤38 ppm), copper (Cu, ≤546 ppm), and zinc (Zn, ≤462 ppm) were observed in both e-liquids and aerosols. We identified the illicit use of leaded bronze in nonheating device components in contact with e-liquid as the source of Pb. Elevated antimony (Sb) in Flum Pebble and Esco Bar samples had unknown origins. Analyses showed Cr was present as nontoxic Cr-(III), while Sb was a mixture of nontoxic Sb-(V) and carcinogenic Sb-(III). Risk assessments revealed cancer risks from Ni and Sb-(III) and noncancer toxicity risks from Pb and Ni exceeded safety thresholds. These findings highlight critical gaps in e-cigarette regulation, characterization, and enforcement, with implications for public health.

Identifiers

PMID40893954
PMCPMC12395296

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.