ArticleKidney medicine2025
Associations of Genetically Predicted CKD With Urinary Tract Cancer and Lung Cancer: A Mendelian Randomization Analysis.
Article in Kidney medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Rationale & Objective: Chronic kidney disease (CKD) is reported to be associated with cancer, especially for urinary tract and lung cancer. However, whether this suggests causality has not been resolved. This study aimed to investigate the causal relation of CKD to overall, urinary tract, and lung cancer. Study Design: Mendelian randomization (MR) analysis. Setting & Participants: Single-nucleotide polymorphism (SNP)-CKD data were obtained from genome-wide association studies of a meta-analysis of CKDGen and UK Biobank. SNP-cancer data from genome-wide association studies of several community-based and cancer-specific consortia were extracted and then meta-analyzed. Exposures: Impaired kidney function (creatinine-based estimated glomerular filtration rate [eGFRcr] <60 mL/min/1.73 m Outcomes: Incidences of overall cancer, urinary tract cancer, and lung cancer. Analytical Approach: Pooled MR estimates of single-SNP Wald ratios were obtained using an inverse variance-weighted method. Results: In inverse variance-weighted MR analyses, a higher genetic liability to impaired kidney function was not significantly associated with higher overall cancer risk (OR, 1.00; 95% CI, 1.00-1.01; Limitations: Uncertain extrapolation to other ethnicities. Conclusions: Genetically predicted CKD is not associated with the risk of incident overall, urinary tract, and lung cancer. Our findings thus provide no genetic evidence for a causal relationship between CKD and cancer.
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