ArticleFrontiers in medicine2025
Associations between Life's Essential 8 scores and systemic immune-inflammation index among American-adult populations without cardiovascular disease.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Relationship Between the "Life's Essential 8" Lifestyle Metrics and Serum High-Sensitivity C-Reactive Protein Levels in South Korea.Life (Basel, Switzerland) · 2026Article
- Research status and hotspots of the systemic immune-inflammation index: A bibliometric analysis.Medicine · 2026Article
- Association of life's essential 8 with depressive symptoms in US cardiovascular disease survivors: a cross-sectional analysis from NHANES 2007-2018.BMC psychology · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cardiovascular health (CVH) profoundly impacts human health and quality of life. Increasing evidence suggests a close association between cardiovascular disease (CVD) and systemic immune-inflammatory levels. This study explores the potential correlation between Life's Essential 8 (LE8) scores and the systemic immune-inflammation index (SII), a novel immune-inflammatory index among US adults. This study provides evidence supporting the role of systemic inflammation reduction in promoting CVH. Methods: Utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007-2018, we investigated information from 21,403 adult participants. Participants were categorized into low CVH (0-49), moderate CVH (50-79), and high CVH (80-100) groups based on LE8 scores. We employed weighted linear regression analysis and subgroup analysis, along with restricted cubic spline curves (RCS) to explore the association between LE8 and SII and the dose-response relationship. Result: A significant negative correlation was found between higher LE8 scores and lower SII levels. Compared to the low CVH group, the β coefficients for SII in the CVH moderate and CVH high groups were -40.02 (95% CI: -58.99 to -21.05, Conclusion: LE8 showed a significant negative correlation with SII. The findings suggest that maintaining higher LE8 scores to some extent promotes CVH and helps alleviate systemic inflammation, potentially benefiting overall health.
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