ArticlePlastic and reconstructive surgery. Global open2025
Long-term Hyperbaric Oxygen Treatment Enhances Nerve Regeneration and Remyelination in a Rat Sciatic Nerve Graft Model.
Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Hyperbaric Oxygen Therapy for Cognitive Impairment Resulting from Neurological Disorders: Mechanisms of Action and Application Advances.International journal of medical sciences · 2026Review
- Nanomaterial-Enhanced Conductive Hydrogels for Peripheral Nerve Repair: Biomimetic Design, Mechanisms, and Translational Challenges.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Peripheral nerve injuries often lead to inconsistent outcomes due to the complexity of nerve regeneration. Hyperbaric oxygen therapy (HBOT) has been proposed to enhance regeneration by improving oxygenation, promoting angiogenesis, and facilitating cellular repair processes. This study evaluated the effects of long-term HBOT on axonal regeneration, remyelination, and functional recovery in a rat model of sciatic nerve injury repaired with autologous nerve grafts. Methods: Forty-two adult male Wistar rats were divided into control (surgery only) and treatment (surgery plus HBOT) groups. HBOT (2 atmospheres absolute, 100% oxygen, 1 h/d, 5 d/wk) was administered for 8 weeks. Functional recovery was assessed using the sciatic functional index, whereas regeneration was evaluated with electrophysiological tests, histological analysis, and immunohistochemistry at postoperative days (PODs) 14, 35, and 90. Results: HBOT enhanced axonal regeneration and remyelination in the middle and distal segments of the graft by POD 35. Motor neuron preservation was significantly higher in the treatment group, approaching levels of uninjured nerves by POD 90. Electrophysiological analyses revealed earlier and more consistent reinnervation in the HBOT group, with improved normalized compound muscle action potential amplitudes at POD 60. However, functional recovery assessed by the sciatic functional index showed no significant differences between groups, likely due to autotomy and the lack of physiotherapy. Conclusions: Long-term HBOT accelerates axonal regeneration and remyelination in a rat model of peripheral nerve injury and grafting. These findings suggest that HBOT is a promising adjunctive therapy for complex nerve injuries, with potential clinical applications in reconstructive nerve surgery.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.