ArticleARYA atherosclerosis2025
Echocardiographic findings of hospitalized children with covid-19: A cross-sectional study in southeast Iran.
Article in ARYA atherosclerosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCardiovascular involvement represents a potentially serious complication associated with novel coronavirus disease 2019 (COVID-19), particularly among pediatric patients. Data regarding echocardiographic findings remain sparse, especially in low- and middle-income countries. The primary objective of this study was to investigate the echocardiographic findings of hospitalized children with COVID-19 in southeast Iran.
methodsThis was a cross-sectional study of hospitalized pediatric COVID-19 patients in Kerman, southeast Iran, between March 2020 and March 2022. Clinical records of patients who had undergone transthoracic echocardiograms were evaluated. Demographic and clinical data, as well as echocardiographic findings-including left ventricular (LV) dysfunction, coronary involvement, valvular abnormalities, and pericardial effusion-were noted. Serum inflammatory markers were also assessed.
resultsData from a total of 188 children were analyzed. The mean age (± standard deviation) was 52.7 ± 4.9 months, and 61.4% were male. In terms of disease severity, 36.1% were categorized as moderate, 47.9% as severe, and 16.0% as multisystem inflammatory syndrome in children (MIS-C). Overall, 92.0% had abnormal echocardiographic findings-most commonly pericardial effusion (55.9%), valvular dysfunction (44.1%), coronary artery involvement (36.7%), and LV dysfunction (19.1%). Mitral regurgitation (36.2%) and tricuspid regurgitation (19.7%) were the most common valvular involvements. Moreover, coronary ectasia (19.7%) and dilatation (13.3%) were the prominent coronary abnormalities. LV dysfunction and valvular abnormalities were associated with increased mechanical ventilation, ICU admission, and mortality. Elevated erythrocyte sedimentation rate (ESR) was associated with valvular dysfunction, while higher NT-proBNP was associated with LV dysfunction.
conclusionHospitalized children had a high prevalence of echocardiographic abnormalities, with LV and valvular dysfunction correlating with worse prognosis and inflammation. Echocardiography appears valuable for risk stratification in ventilator support and Intensive Care Unit (ICU) admission in pediatric patients; however, further research is needed on long-term cardiac sequelae.
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