Evidence map›Paper›PMID 40893681›Full record

ArticleActa pharmaceutica Sinica. B2025

Macrophage DGK

Yumeng Miao, Tzuchun Lin, Bianlin Wang, Junyu Xu, Chongxian Li, Zuopeng Li, Xinwen Zhang, Chendong Zhou, Tuerganaili Aji, Minjia Tan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yumeng MiaoDepartment of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Tzuchun LinDepartment of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Bianlin WangXinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.
Junyu XuShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Chongxian LiSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Zuopeng LiXinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.
Xinwen ZhangShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Chendong ZhouShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Tuerganaili AjiThe First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Minjia TanShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Haji Akber AisaXinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.
Jingya LiShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute liver failure (ALF) is a life-threatening condition associated with macrophage-mediated inflammatory responses. Effective therapies and drugs are still lacking to date. Here, we reveal that a derivative of xanthohumol, CAM12203, alleviates lipopolysaccharide (LPS) + d-galactosamine (D-GalN)-induced ALF through limiting macrophage-mediated inflammation, with the most significant impact on interleukin-1

Indexed as

Acute liver failureDiacylglycerol kinase ζInflammationInterleukin-1βMacrophagesPhosphatidic acidSignal transducer and activator of transcription 3Xanthohumol derivative

Identifiers

PMID40893681
PMCPMC12399221

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.