Case report of isolated aortic valve AL-amyloidosis following aortic valve replacement.

Rajin Choudhury, Victor H Jimenez-Zepeda, Etienne Mahe, Nowell M Fine

Abstract readCase Reports

In one paragraph

Article in European heart journal. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Amyloidosis and Thoracic Aortic Disease: A Scoping Review.Journal of clinical medicine · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rajin ChoudhuryDivision of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada T2N 1N4.ORCID https://orcid.org/0000-0002-8533-1786

Victor H Jimenez-ZepedaDepartment of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 1N4.ORCID https://orcid.org/0000-0002-6220-5955

Etienne MaheDepartment of Pathology and Laboratory Medicine, Department of Medicine, University of Calgary, Calgary, Canada AB T2N 1N4.ORCID https://orcid.org/0000-0002-6559-9339

Nowell M FineDivision of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada T2N 1N4.ORCID https://orcid.org/0000-0002-6546-6587

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Light chain (AL)-amyloidosis is a haematologic malignancy where cardiac involvement confers a worse prognosis. There is a recognized association between aortic stenosis (AS) and transthyretin amyloidosis (ATTR) cardiomyopathy. However, there is no such reported association with AL amyloidosis. Case summary: We present a case of degenerative AS where the pathology analysis post-surgical replacement demonstrated amyloid deposits subsequently identified as AL subtype by mass spectrometry. Subsequent investigations demonstrated no myocardial or systemic involvement. Following multidisciplinary discussion, cardiac biopsy and chemotherapy were deferred given the isolated nature of aortic valve involvement and clinical stability. Discussion: Incidental detection of aortic valve AL-amyloidosis in this case demonstrates that such deposits cannot be assumed to be ATTR, and further work-up and amyloid typing is necessary.

Indexed as

Aortic stenosisAortic valve replacementCardiac AL-amyloidosisCase report

Identifiers

PMID40893643

DOI10.1093/ehjcr/ytaf393

PMCPMC12397050

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