Evidence map›Paper›PMID 40893584›Full record

ArticleIn silico pharmacology2025

Ayodeji O Falade, Megan D Akingbasote, Kayode E Adewole, Odunayo M Agunloye, Ahmed A Ishola, Aimen Aljoundi, Ghazi Elamin, Kolawole A Olofinsan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In silico pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ayodeji O FaladeBiotechnology, Computational Biochemistry and Phytomedicine Research Group, Department of Biochemistry, University of Medical Sciences, Ondo, Ondo State Nigeria.ORCID 0000-0001-9548-5749
Megan D AkingbasoteBiotechnology, Computational Biochemistry and Phytomedicine Research Group, Department of Biochemistry, University of Medical Sciences, Ondo, Ondo State Nigeria.
Kayode E AdewoleBiotechnology, Computational Biochemistry and Phytomedicine Research Group, Department of Biochemistry, University of Medical Sciences, Ondo, Ondo State Nigeria.ORCID 0000-0002-6761-3798
Odunayo M AgunloyeFunctional Foods, Nutraceuticals and Phytomedicine Unit, Department of Biochemistry, Federal University of Technology, Akure, Ondo State Nigeria.ORCID 0000-0002-8835-0472
Ahmed A IsholaCentral Research Laboratories Limited, 132B, University Road, Ilorin, Kwara State Nigeria.ORCID 0000-0002-5395-5922
Aimen AljoundiDepartment of Medicinal Chemistry, College of Pharmacy, Attahadi University, Tripoli, V567-7M8 Libya.ORCID 0000-0002-4773-1121
Ghazi ElaminDepartment of Anaesthesiology & Critical Care, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.ORCID 0000-0003-0621-9057
Kolawole A OlofinsanDepartment of Pharmacology, University of the Free State, Bloemfontein, 9300 South Africa.ORCID 0000-0002-2987-0996

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cinnamon and coriander plants are sources of popular spice products in different cuisines prepared by many people worldwide. The inhibitory effect of cinnamon bark and coriander seeds aqueous extracts on butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) activities, and their antioxidant properties were investigated using in vitro, molecular docking and molecular dynamics (MD) computational models. Standard experimental methods were employed to determine the plant extracts' antioxidant and enzyme-inhibitory capacities. Subsequently, chemically annotated metabolites from the extracts were subjected to MD with the enzymes before the ligand-protein complexes of two compounds with the highest docking scores were subjected to MD at 300 ns. Phytochemical profiling of extracts from the plants via Gas Chromatography-Mass Spectrometry analysis revealed the presence of polyphenols, flavonoids, terpenes and their derivatives. The extracts from the plant inhibited the investigated cholinergic proteins, although no significant differences (

Indexed as

Alzheimer’s diseaseAntioxidantsCholinesterase inhibitorsMolecular dynamicsNeurodegenerative disorders

Identifiers

PMID40893584
PMCPMC12390917

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.