ArticleQuantitative imaging in medicine and surgery2025
Association of decreased thalamic neurotransmitter level with sensorimotor tract damage in patients with relapsing-remitting multiple sclerosis.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Thalamic microstructural damage and neurotransmission dysfunction are present in patients with multiple sclerosis (MS). The aim of this study was to investigate the relationship of altered γ-aminobutyric acid (GABA) and glutamate + glutamine (Glx) levels in the thalamus with the white-matter (WM) microstructural damage of the sensorimotor tract in patients with relapsing-remitting MS (RRMS). Methods: In this cross-sectional study, 50 patients with RRMS and 43 healthy controls (HCs) were scanned using Mescher-Garwood point resolved spectroscopy (MEGA-PRESS) to quantify the GABA+ and Glx level of the thalamus. Metrics derived from diffusion tensor imaging (DTI) were calculated to reflect the degree of WM microstructural damage of the sensorimotor tract. The correlation between neurotransmitter level and diffusion metrics was determined in patients with RRMS and HCs, respectively. Results: Thalamic GABA+ and Glx levels were significantly decreased in patients with RRMS as compared with HCs (GABA+: 2.859±0.451 Conclusions: Neurotransmitters may play an important role in the pathophysiologic mechanisms of MS. Our study suggests an association between altered GABA and glutamate levels in deep gray-matter and WM microstructural damage in the sensorimotor tract.
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