ArticleQuantitative imaging in medicine and surgery2025
Evaluation of skeletal muscle microcirculation via magnetic resonance intravoxel incoherent motion perfusion imaging in an acute ischemia rabbit model.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Acute limb ischemia (ALI) necessitates prompt intervention to prevent severe complications such as amputation. Current clinical assessments lack reliable quantitative methods for gauging skeletal muscle ischemia severity. Intravoxel incoherent motion (IVIM) perfusion imaging is a noninvasive approach for quantifying microvascular perfusion. We aimed to assess microcirculation alterations in rabbit vastus lateralis muscle following acute ischemia using IVIM. Methods: Acute ischemia models were established in 25 New Zealand white rabbits through arterial ligation of their right hind legs. Magnetic resonance imaging (MRI) examinations of the vastus lateralis muscle were conducted hourly postsurgery for a duration of 7 hours. The scan sequences included IVIM, adenosine triphosphate (APT), T1-weighted imaging (T1WI), T2-weighted imaging with fat suppression (T2WI-FS), T2 mapping, and diffusion-weighted imaging (DWI). The correlations between MRI results, ischemic time, and pathological changes were analyzed. Results: The perfusion fraction (f) of ischemic muscle significantly decreased from 6.19%±1.13% at 1 hour to 2.50%±0.64% at 7 hours (control: 7.19%±1.03%), representing a strong negative correlation with ischemic duration (r=-0.790). The true diffusion coefficient (D) remained relatively stable [(1.41-1.46)×10 Conclusions: MRI effectively visualizes and detects skeletal muscle ischemia, with IVIM-derived f values providing a quantitative measure of microcirculatory impairment. D* potentially serves as a biomarker for identifying irreversible muscle fiber damage and may be a valuable tool for the quantitative assessment of ischemic injury to skeletal muscle.
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