ReviewNew microbes and new infections2025
Anti-TB treatment outcomes in TB meningitis: A systematic review and meta-analysis.
Review in New microbes and new infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Epidemiological trends and neurological outcomes of pediatric central nervous system infections in rural part of western India.World journal of clinical pediatrics · 2026Article
- Automated machine learning model to predict anti-tuberculosis drug-induced liver injury in patients with tuberculous meningitis.Frontiers in pharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Introduction: Tuberculous meningitis (TBM) remains a leading cause of mortality and neurological disability in both children and adults. This systematic review and meta-analysis aim to assess the treatment outcomes of anti-tuberculosis drugs in TBM patients, focusing on mortality and neurological disability. Methods: We conducted a comprehensive literature search on PubMed/MEDLINE, EMBASE, and Cochrane CENTRAL databases to identify articles reporting treatment outcomes in TBM up to December 15, 2024. Studies included in the analysis reported treatment outcomes for TBM patients. Pooled analyses were performed using random-effects model to assess mortality rates, neurological disability, and loss to follow-up. Results: A total of 10 studies involving 2005 patients were included in the analysis. The pooled all-cause mortality rate across studies was 27.7 % (95 % CI: 22.6-33.4 %, Conclusions: This study highlights the high mortality and significant neurological disability in TBM patients, particularly in HIV-positive individuals. Our findings emphasize the need for standardized outcome reporting and the incorporation of new therapeutic strategies, and improved diagnostic tools, to enhance clinical outcomes. Future research should focus on addressing these areas to optimize treatment protocols and reduce the burden of TBM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.