ReviewThe World Allergy Organization journal2025
Discontinuation of biologic therapy in severe asthma: Evidence and strategies for safe withdrawal: A scoping review.
Review in The World Allergy Organization journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Switching to twice-yearly depemokimab from mepolizumab/benralizumab in severe asthma: a multicenter, randomized, double-blind, phase 3A clinical trial (NIMBLE).American journal of respiratory and critical care medicine · 2026Trial
- Biological treatments for asthma and chronic obstructive pulmonary disease.BMJ medicine · 2026Review
- Clinical and Cost-Effectiveness of Omalizumab in Concomitant Asthma and Chronic Rhinosinusitis with Nasal Polyps: A Real-World Exploratory Study.Journal of asthma and allergy · 2026Article
- Predictive Factors And Treatments Associated with Clinical Remission in Severe Eosinophilic Asthma.Journal of inflammation research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Severe asthma is characterized by poor disease control despite the use of high-dose inhaled corticosteroids and long-acting bronchodilators. Biologic therapies have revolutionized its management, allowing some patients to achieve remission. However, uncertainty remains regarding the optimal duration of treatment and the safest strategies for discontinuation. This study reviews the available evidence on the withdrawal of biologic therapy in patients with severe asthma in remission, evaluating their clinical outcomes. Methods: A literature review was conducted in PubMed, EMBASE, Epistemonikos, and LILACS up to May 2024, using terms related to severe asthma and discontinuation of biologic therapies. Studies evaluating asthma control after dose reduction or withdrawal of biologic treatment were included, considering outcomes such as exacerbations, lung function, and inflammatory biomarkers. Results: Of the 2494 studies identified, 23 articles were included after full-text review. Discontinuation of tezepelumab led to a gradual loss of clinical control in most patients, although baseline levels of inflammation were not reached. Regarding mepolizumab, 59% of patients experienced at least 1 significant exacerbation within the first year after withdrawal, suggesting the need for prolonged use. For omalizumab, results were heterogeneous: 67% of patients who continued treatment remained exacerbation-free, compared to 47.7 of those who discontinued it. Studies that implemented gradual tapering strategies showed higher success rates in discontinuation without loss of clinical control. Conclusion: Evidence suggests that discontinuation of biologic therapy should be individualized, and a minimum treatment duration of 5 years may be appropriate before considering withdrawal. Optimal candidates include those with sustained clinical control, stable lung function, suppressed inflammatory biomarkers, and no need for oral corticosteroids. Gradual decreasing strategies may optimize treatment withdrawal while minimizing the risk of relapse.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.