ArticleImaging neuroscience (Cambridge, Mass.)2025
Neural micro and macrostructural correlates of visual outcomes in children with unilateral cerebral palsy: A fixel-based study.
Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Children with unilateral cerebral palsy (uCP) present with brain damage, predominantly lateralized to one hemisphere, and white matter (WM) lesions, which are known to affect visual functions. However, the relation between WM tract damage and visual outcomes remains unclear. Additionally, no prior study comprehensively investigated hemispheric-specific differences in WM visual pathways between children with left- and right-sided uCP. Therefore, this exploratory study aims to investigate differences in micro- and macrostructural properties of the visual pathways between children with left- and right-sided uCP and their relation to visual outcomes, using fixel-based analysis of diffusion MRI (dMRI). dMRI data and visual assessments, including visual acuity and stereoacuity (i.e., geniculostriate functions), motor-free visual perception, visuomotor integration, and functional vision, were analysed in 36 children with uCP (aged 7-15, 9 males, 17 left-sided, 15 preterm). Apparent fiber density (AFD), fiber-bundle cross-section (FC), and combined fiber density and cross-section (FDC) were calculated for 17 WM tracts related to visual functions. Differences between children with left- and right-sided uCP were investigated using the Mann-Whitney
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