Evidence map›Paper›PMID 40893448›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2025

On the analysis of functional PET (fPET)-FDG: Baseline mischaracterization can introduce artifactual metabolic (de)activations.

Sean E Coursey, Joseph Mandeville, Murray B Reed, Grant A Hartung, Arun Garimella, Hasan Sari, Rupert Lanzenberger, Julie C Price, Jonathan R Polimeni, Douglas N Greve and 2 more

Abstract read
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Task-evoked deactivations: dissociation between BOLD fMRI and FDG.bioRxiv : the preprint server for biology · 2026
    Article
  2. High-temporal resolution metabolic connectivity resolved by component-based noise correction.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Sean E CourseyAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States.
Joseph MandevilleAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States.
Murray B ReedDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Grant A HartungAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States.
Arun GarimellaAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States.
Hasan SariAdvanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland.
Rupert LanzenbergerDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Julie C PriceAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States.
Jonathan R PolimeniAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States.
Douglas N GreveAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States.
Andreas HahnDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Jingyuan E ChenAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States.

Funding

Probing the Biophysical Basis of Large-Scale Brain Dynamics Using Simultaneous PET/fMRI and EEG/PET/fMRIR00NS118120 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CHEN, JINGYUAN · 2023 to 2025
$735k
Multi-modal imaging of the metabolic and neurochemical mechanisms underlying task-evoked negative BOLD signalsR21MH135201 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI CHEN, JINGYUAN · 2024 to 2025
$459k
NIMH NIH HHS R21 MH135201NINDS NIH HHS R00 NS118120
6 · The paper itself

Abstract

Functional Positron Emission Tomography (fPET) with (bolus plus) constant infusion of [

Indexed as

functional PET-FDGglucose metabolismmetabolic activationstatistical analysis

Identifiers

PMID40893448
PMCPMC12395282

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.