ArticleCommunications physics2024
Excitable dynamics driven by mechanical feedback in biological tissues.
Article in Communications physics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Optoelectronic Interfaces for Nongenetic Modulation of Excitable Tissues.Small methods · 2026Review
- Learning Epithelial Elasticity via Local Tension Remodeling.bioRxiv : the preprint server for biology · 2025Article
- Fluidization and anomalous density fluctuations in 2D Voronoi cell tissues with pulsating activity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mechanochemical dynamics of collective cells and hierarchical topological defects in multicellular lumens.Science advances · 2024Article
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Authors and funding
3 authors.
Funding
Abstract
Pulsatory activity patterns, driven by mechanochemical feedback, are prevalent in many biological systems. However, the role of cellular mechanics and geometry in the propagation of pulsatory signals remains poorly understood. Here we present a theoretical framework to elucidate the mechanical origin and regulation of pulsatile activity patterns within excitable multicellular tissues. We show that a simple mechanical feedback at the level of individual cells - activation of contractility upon stretch and subsequent inactivation upon turnover of active elements - is sufficient to explain the emergence of quiescent states, long-range wave propagation, and traveling activity pulse at the tissue-level. We find that the transition between a propagating pulse and a wave is driven by the competition between timescales associated with cellular mechanical response and geometrical disorder in the tissue. This sheds light on the fundamental role of cell packing geometry on tissue excitability and spatial propagation of activity patterns.
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Registered trials
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