Evidence map›Paper›PMID 40893415›Full record

ArticleApplied microbiology (Basel, Switzerland)2025

Gallium Resistance in

Akamu Ewunkem, Felicia Simpson, David Holland, Tatyana Bowers, Ariyon Bailey, Ja'nyah Gore, Uchenna Iloghalu, Vera Williams, Sarah Adjei-Fremah, Larisa Kiki and 1 more

Abstract read
In one paragraph

Article in Applied microbiology (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Akamu EwunkemDepartment of Biological Sciences, Winston Salem State University, Winston-Salem, NC 27110, USA.ORCID 0000-0003-3441-9881
Felicia SimpsonDepartment of Mathematics, Winston Salem State University, Winston-Salem, NC 27110, USA.
David HollandDepartment of Mathematics, Winston Salem State University, Winston-Salem, NC 27110, USA.
Tatyana BowersDepartment of Mathematics, Winston Salem State University, Winston-Salem, NC 27110, USA.
Ariyon BaileyDepartment of Biological Sciences, Winston Salem State University, Winston-Salem, NC 27110, USA.
Ja'nyah GoreDepartment of Biological Sciences, Winston Salem State University, Winston-Salem, NC 27110, USA.
Uchenna IloghaluDepartment of Biological Sciences, Winston Salem State University, Winston-Salem, NC 27110, USA.ORCID 0000-0002-5938-0664
Vera WilliamsUNC Health Care Hillsborough, Hillsborough, NC 27278, USA.
Sarah Adjei-FremahDepartment of Biological Sciences, Winston Salem State University, Winston-Salem, NC 27110, USA.
Larisa KikiDepartment of Applied Sciences, North Carolina A and T State University, Greensboro, NC 27411, USA.
Brittany JusticeDepartment of Biological Sciences, Winston Salem State University, Winston-Salem, NC 27110, USA.

Funding

Genomic Research and Data Science Center for Computation and Cloud-ComputingU24HG013013 · NHGRI · NORTH CAROLINA AGRI & TECH ST UNIV · PI CHRISTOPHER C DOSS, Joseph L Graves · 2023 to 2026
$6.0M
NHGRI NIH HHS U24 HG013013
6 · The paper itself

Abstract

Background and Objectives: The imminent threat of antibiotic resistance has spurred studies of nonconventional antimicrobial approaches. Gallium utilization is a promising and emerging approach to treating a variety of resistant bacteria using "Trojan horse" strategies to disrupt iron-dependent processes and biofilms. This study utilized experimental evolution to test the evolvability of gallium resistance in Methods: Whole-genome sequencing was utilized to reveal functional networks of mutations associated with gallium resistance. Additionally, scanning electron microscopy (SEM) observation was utilized to visualize distinct morphological changes on the surface of gallium-resistant populations and compare with the control populations. Results: As demonstrated by these studies, Conclusions: Our study confirmed that using gallium as an antimicrobial can have significant health and environmental implications.

Indexed as

galliummetalspolyfluorinated compoundspolymorphismsselectionStaphylococcus aureus

Identifiers

PMID40893415
PMCPMC12393781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.