Multifunctional and endogenous stimuli-responsive vinblastine sulfate/manganese dioxide nanodrugs for enhancing chemotherapeutic efficacy against hypoxic tumors.

Yong Geun Lim, Yeji Chang, Seon-Ju Park, Kyoung-Dong Kim, Kyeongsoon Park

Abstract read

In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

A pH/HInternational journal of nanomedicine · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yong Geun LimDepartment of Systems Biotechnology, Chung-Ang University, Anseong, Gyeonggi, 17546, South Korea.

Yeji ChangDepartment of Systems Biotechnology, Chung-Ang University, Anseong, Gyeonggi, 17546, South Korea.

Seon-Ju ParkDepartment of Systems Biotechnology, Chung-Ang University, Anseong, Gyeonggi, 17546, South Korea.

Kyoung-Dong KimDepartment of Systems Biotechnology, Chung-Ang University, Anseong, Gyeonggi, 17546, South Korea.

Kyeongsoon ParkDepartment of Systems Biotechnology, Chung-Ang University, Anseong, Gyeonggi, 17546, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several solid tumors contain large hypoxic regions, diminishing drug responses and resulting in limited therapeutic outcomes. Vinblastine sulfate (VBL) targets the tubulin molecule, causing microtubule depolymerization and inducing mitotic arrest, leading to tumor regression. However, hypoxia causes microtubule depolymerization in tumor cells, reducing the number of intact microtubules for drug binding and diminishing the efficacy of microtubule-targeting agents like VBL. Therefore, to relieve tumor hypoxia and enhance chemotherapeutic responses to hypoxic tumors, we developed multifunctional and endogenous stimuli-responsive VBL/manganese dioxide (VBL/MnO

Indexed as

ChemotherapyManganese dioxide (MnO2)Oxygen-generating materialsTumor hypoxia reliefTumor microenvironment (TME)Vinblastine sulfate (VBL)

Identifiers

PMID40893378

DOI10.1016/j.mtbio.2025.102229

PMCPMC12398928

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.