Evidence map›Paper›PMID 40893364›Full record

ArticleMaterials today. Bio2025

A near-infrared responsive photocaged amplified DNA nanodevice for precise and sensitive microRNA imaging.

Yan Zhong, Zheng Li, Bo Li, Chang Xu, Tuya Bai, Hang Qian, Chunyan Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yan ZhongDepartment of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010020, China.
Zheng LiDepartment of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010020, China.
Bo LiDepartment of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010020, China.
Chang XuDepartment of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010020, China.
Tuya BaiNew Drug Screening Engineering Research Center of Inner Mongolia Autonomous Region, Inner Mongolia Medical University, Hohhot, 010000, China.
Hang QianDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, 400037, China.
Chunyan WangDepartment of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010020, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) play a critical role in early cancer detection, but traditional DNA probes are limited by the low abundance of miRNAs and their "always effective" property. Herein, we construct a photocaged amplified DNA nanodevice (PAD) by attaching DNA probes to upconversion nanoparticles (UCs). Upon remote near-infrared (NIR) light stimulation, the photocleavable DNA probes are activated by emitted UV light, and subsequently triggered by target miRNA. This process is further propelled by mRNA and DNA hairpin to achieve "one to many" signal amplification, enabling precise and sensitive spatiotemporal resolved imaging of miRNA.

Indexed as

In situ activationmiRNA imagingPhoto-cleavable DNA probesSignal amplificationUpconversion nanoparticles

Identifiers

PMID40893364
PMCPMC12396463

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.