Evidence map›Paper›PMID 40893362›Full record

ArticleMaterials today. Bio2025

Multifunctional Prussian lue nanozymes ameliorate tendinopathy via modulating tissue homeostasis.

Junyao Yang, Jian Chen, Yixiao Liu, Xinghe Zhao, Zheyi Chen, Haodong Zheng, Fangyi Chen, Hongyu Yan, Xiaojun Cai, Jing Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. The Role of Phagocytic Cells in the Achilles Tendon.International journal of molecular sciences · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Junyao YangDepartment of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, PR China.
Jian ChenDepartment of Pediatric Orthopedics, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, PR China.
Yixiao LiuShanghai Key Laboratory of Neuro-Ultrasound for Diagnosis and Treatment, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, PR China.
Xinghe ZhaoDepartment of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, PR China.
Zheyi ChenDepartment of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, PR China.
Haodong ZhengDepartment of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, PR China.
Fangyi ChenDepartment of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, PR China.
Hongyu YanShanghai Key Laboratory of Neuro-Ultrasound for Diagnosis and Treatment, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, PR China.
Xiaojun CaiShanghai Key Laboratory of Neuro-Ultrasound for Diagnosis and Treatment, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, PR China.
Jing XuDepartment of Pediatric Orthopedics, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tendinopathy, a prevalent musculoskeletal disorder characterized by chronic pain and functional decline, remains a therapeutic challenge due to the limited efficacy of conventional treatments in addressing oxidative stress and persistent inflammation. Here, we present Prussian blue nanozymes (PBzymes) as a catalytic nanomedicine engineered to mimic multi-enzyme activities, offering a potent strategy for tendon microenvironment modulation and repair. Synthesized via a hydrothermal template-free approach, PBzymes exhibit robust reactive oxygen species (ROS)-scavenging capabilities through intrinsic superoxide dismutase, catalase, and peroxidase-like activities, effectively neutralizing •OH, H

Indexed as

InflammationNanozymePrussian blueReactive oxygen speciesTendinopathy

Identifiers

PMID40893362
PMCPMC12390960

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.