Evidence map›Paper›PMID 40893356›Full record

ArticleMaterials today. Bio2025

Intravenously injected poly(amino acid) nanoformulation relieves spinal cord injury through synergistical modulation of microenvironments.

Yuehong Li, Qingzheng Zhang, Zongtai Liu, Weiguo Xu, Changfeng Fu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuehong LiDepartment of Spine Surgery, Center of Orthopedics, The First Hospital of Jilin University, 1 Xinmin Street, Changchun, 130061, PR China.
Qingzheng ZhangDepartment of Spine Surgery, Center of Orthopedics, The First Hospital of Jilin University, 1 Xinmin Street, Changchun, 130061, PR China.
Zongtai LiuDepartment of Spine Surgery, Center of Orthopedics, The First Hospital of Jilin University, 1 Xinmin Street, Changchun, 130061, PR China.
Weiguo XuState Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR China.
Changfeng FuDepartment of Spine Surgery, Center of Orthopedics, The First Hospital of Jilin University, 1 Xinmin Street, Changchun, 130061, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The microenvironments play a crucial role in secondary injury following spinal cord injury (SCI). Deterioration of the microenvironments, including oxidative stress, inflammation, and excitotoxicity, exacerbates SCI. However, due to the complexity of these microenvironments, synergistic modulation of multiple factors remains challenging. In this study, we developed a reactive oxygen species (ROS) responsive nanoformulation system based on a methoxy poly(ethylene glycol)-

Indexed as

Anti-InflammationModulation of microenvironmentsNeuroprotectionpoly(amino acid) nanoformulationSpinal cord injury therapy

Identifiers

PMID40893356
PMCPMC12398927

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.