Evidence map›Paper›PMID 40893348›Full record

ArticleMaterials today. Bio2025

Submicron-oleogel particles for enhanced oral delivery of hydrophobic compounds:

Areen Ashkar, Rania Awad, Uri Lesmes, Alejandro Sosnik, Maya Davidovich-Pinhas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Areen AshkarLaboratory of Food Materials Engineering, Faculty of Biotechnology and Food Engineering, Technion - Israel Institute of Technology, Haifa, 3200003, Israel.
Rania AwadLaboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion - Israel Institute of Technology, Haifa, 3200003, Israel.
Uri LesmesLabratory of Chemistry of Foods, Bioactives and Digestion, Faculty of Biotechnology and Food Engineering, Technion - Israel Institute of Technology, Haifa, 3200003, Israel.
Alejandro SosnikLaboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion - Israel Institute of Technology, Haifa, 3200003, Israel.
Maya Davidovich-PinhasLaboratory of Food Materials Engineering, Faculty of Biotechnology and Food Engineering, Technion - Israel Institute of Technology, Haifa, 3200003, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral administration is the preferred route for drug and bioactive delivery, although it raises great challenges due to the involvement of the gastrointestinal system and limited bioavailability. Herein, a novel submicron-oleogel particle system was developed using micro-structured edible oil to address the challenges associated with the low bioavailability of oral hydrophobic compounds. Oleogel particles were prepared using β-sitosterol and γ-oryzanol as oil structuring agents with dispersed dasatinib as a model drug. A particle size of approximately 160 nm and zeta-potential of around -25 mV were achieved along with a high drug entrapment efficiency of ∼90 %.

Indexed as

Colloidal structuresDigestionMicellizationOleogelOral delivery

Identifiers

PMID40893348
PMCPMC12398780

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.