ArticleACS omega2025
A Biomaterial-Based Approach to Trypsin Sensing: Design and Optimization of Gelatin-Casein Films.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Wrinkle-Adaptive Kirigami Wearables With Anisotropic Deformability for Sleep EEG Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Real-time postoperative monitoring systems have tremendous potential to detect postoperative complications faster before patients become systemically ill. This study investigates the potential of gelatin-casein blend films as a biodegradable, implantable biomaterial platform for trypsin detection, which is a potential biomarker for an anastomotic leak from the duodenum or proximal jejunum. Although implantability has not been verified in this case, the implantability of gelatin and casein-based biomaterials is substantiated by their demonstrated cytocompatibility as evidenced below and established utility in medical applications, as evidenced by recent advancements in biomaterials research. We systematically evaluated nine gelatin-casein blends, ranging from 0:100 to 100:0 ratios to optimize their enzymatic degradability and response, establishing a material platform for future biosensing applications. Optimal refers to the sensor's ability to rapidly detect physiological concentrations of trypsin in the body while generating the maximum detectable response. Characterization of the films was performed using Fourier-Transform Infrared Spectroscopy (FTIR), UV-visible Spectroscopy (UV-vis), and Quartz Crystal Microbalance (QCM). The films' responses to trypsin were analyzed through limit of detection, initial reaction rates, and absorbance shifts. For statistical analysis, a flexible exponential decay model, was employed to assess the significance of the results. Our findings reveal that the 75:25 casein:gelatin blend exhibits superior performance, with the lowest limit of detection (7.81 × 10
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Registered trials
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