Evidence map›Paper›PMID 40893272›Full record

ArticleACS omega2025

Green Efficient Synthesis of [1,3,4]Thiadiazole-Tethered Alkoxyaryl Hydrazones: Evaluation of Antitumor Activities and Molecular Docking Studies.

Nahlah A Alhadhrami, Sayed M Riyadh, Mohamed S M Ahmed, Zeinab A Abdallah, Thoraya A Farghaly, Shadia M Hussein

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nahlah A AlhadhramiChemistry Department, Faculty of Science, Taibah University, Al-Madinah, Almunawrah 30002, Saudi Arabia.
Sayed M RiyadhDepartment of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt.ORCID https://orcid.org/0000-0002-0329-6674
Mohamed S M AhmedDepartment of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt.
Zeinab A AbdallahDepartment of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt.
Thoraya A FarghalyDepartment of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt.ORCID https://orcid.org/0000-0002-9620-8548
Shadia M HusseinChemical Pathology Department, Cairo University Hospital, Cairo University, Giza 12613, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrazono-[1,3,4]-thiadiazoles have a prominent position among the heterocyclic compounds due to their broadening aspects of biological activities. In the current study, a neoteric series of [1,3,4]-thiadiazoles tethered to alkoxyaryl hydrazone has been formulated via the treatment of methyl 2-[3-(pentyloxy)-benzylidene]-hydrazine-1-carbodithioate and hydrazonoyl chlorides in ethanolic solution under thermal conditions. DABCO, as an environmentally nontoxic material, was utilized as a superior basic catalyst for the latter reaction. The structures of the isolated products were explicated by spectral (IR, NMR, and MS) and elemental analysis tools. The antitumor activity of the synthesized products was assessed against the breast cancer MCF-7 cell line. The results displayed that compounds

Identifiers

PMID40893272
PMCPMC12392172

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.