ArticleACS omega2025
Potential Antiphotoaging Effect of Human Cathelicidin LL-37 Fragments and KR-12 Analogs on UVB-Induced HaCaT Cells and UVA-Induced HDF Cells.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
Cathelicidin LL-37, an antimicrobial peptide (AMP) of the innate immune system, wards off bacterial infections. Recent research has identified plenty of biological functions of AMPs beyond their antimicrobial activity, including antioxidant, self-renewal, and procollagen properties, making them valuable for antiaging products. In this study, we assessed the antiphotoaging potential of cathelicidin LL-37 fragments and KR-12 analogs using human immortalized keratinocytes (HaCaT) and human dermal fibroblasts (HDF). Our results reveal that these peptides can modulate ultraviolet-radiation-induced photodamage, exhibiting anti-inflammatory and antioxidant properties. Notably, we proved the immune modulation effects of LL-23. Additionally, these peptides promote cell migration and collagen synthesis, inhibit glycation, and suppress melanin production. We propose that the antiphotoaging effects exhibited by LL-37 fragments and KR-12 analogs are related to the alleviation of inflammation, and we attempt to elucidate the possible underlying mechanisms. These findings support their efficacy as antiaging agents in dermatological applications.
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