ArticleFrontiers in public health2025
Temporal dynamics of SARS-CoV-2 detection in wastewater and population infection trends in Mexico City.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Wastewater-based epidemiology (WBE) provides a non-invasive, community-level approach to monitor infectious diseases such as COVID-19. This study investigated the temporal relationship between SARS-CoV-2 RNA levels in wastewater and reported COVID-19 cases in adjacent populations in Mexico City. A total of 40 samples were collected from the Copilco neighborhood during two epidemiological waves (April-September 2021 and November 2021-February 2022). An optimized one-step RT-qPCR protocol targeting the N1 gene achieved 96.7% efficiency with a detection limit of 10 copies/μL. Spatial classification identified three proximity zones based on drainage system topology. Cross-correlation analysis between viral genome copies and confirmed case data revealed a significant temporal lag of 6-8 days. These results support the application of WBE as an early-warning tool to inform public health strategies and anticipate infection trends.
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