Evidence map›Paper›PMID 40893156›Full record

Article3 Biotech2025

Synthesis and structural characterization of coumarin-hydrazone derivatives as antiplatelet agents: in vitro and in silico evaluation of activity and toxicity.

Asma Haffouz, Emna Khdhiri, Ines Dhouib, Ikram Ben Amor, Amira Jerbi, Jalel Gargouri, Emna Sahli, Noureddine Allouche, Ali Gargouri, Gérard Lizard and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in 3 Biotech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Asma HaffouzLaboratory of Molecular Biotechnology of Eucaryotes, Centre of Biotechnology of Sfax, University of Sfax, B.P 1177, 3018 Sfax, Tunisia.
Emna KhdhiriLaboratoire de Chimie Appliquée "Hétérocycles Corps Gras & Polymères", Faculté des Sciences, Université de Sfax, 3038 Sfax, Tunisie.
Ines DhouibLaboratory of Plant Biotechnology, Faculty of Sciences of Sfax, University of Sfax, BP 1171, 3038 Sfax, Tunisia.
Ikram Ben AmorLaboratory of Hematology (LR19SP04), Medical Faculty of Sfax, University of Sfax, Magida Boulila Avenue, 3029 Sfax, Tunisia.
Amira JerbiLaboratory of Hematology (LR19SP04), Medical Faculty of Sfax, University of Sfax, Magida Boulila Avenue, 3029 Sfax, Tunisia.
Jalel GargouriLaboratory of Hematology (LR19SP04), Medical Faculty of Sfax, University of Sfax, Magida Boulila Avenue, 3029 Sfax, Tunisia.
Emna SahliAnalytical Service Provider Unit, Centre of Biotechnology of Sfax, University of Sfax, 3018 Sfax, Tunisia.
Noureddine AlloucheLaboratory of Organic Chemistry LR17ES08 (Natural Substances Team), Faculty of Sciences of Sfax, University of Sfax, Sfax, Tunisia.
Ali GargouriLaboratory of Molecular Biotechnology of Eucaryotes, Centre of Biotechnology of Sfax, University of Sfax, B.P 1177, 3018 Sfax, Tunisia.
Gérard LizardLaboratoire Interdisciplinaire Carnot de Bourgogne ICB UMR 6303 (Team Prof. Nadine Millot), University Bourgogne Europe, CNRS, Inserm, 21000 Dijon, France.
Souhir AbidChemistry Department, College of Science and Arts, Jouf University, Jouf, Saudi Arabia.
Houcine AmmarLaboratoire de Chimie Appliquée "Hétérocycles Corps Gras & Polymères", Faculté des Sciences, Université de Sfax, 3038 Sfax, Tunisie.
Bassem KhemakhemLaboratory of Plant Biotechnology, Faculty of Sciences of Sfax, University of Sfax, BP 1171, 3038 Sfax, Tunisia.
Basma HadjKacemLaboratory of Molecular Biotechnology of Eucaryotes, Centre of Biotechnology of Sfax, University of Sfax, B.P 1177, 3018 Sfax, Tunisia.ORCID 0009-0004-5931-6162

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this work is the synthesis of nine coumarin-hydrazone derivatives and their characterization by IR, 1D NMR, 2D NMR, NOESY, and elemental analysis, as well as the evaluation of their antiplatelet activity through in vitro and in silico tests. Among the tested series, compounds Supplementary Information: The online version contains supplementary material available at 10.1007/s13205-025-04495-z.

Indexed as

ADMET predictionAntiplateletCoumarin–hydrazoneCytotoxicityDocking

Identifiers

PMID40893156
PMCPMC12398456

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.