Evidence map›Paper›PMID 40893051›Full record

ArticleJCO precision oncology2025

Case-Control Study for 23 Cancer Types With Functional Analysis of

Yuri Takehara, Yoshiaki Usui, Lenka Stolařová, Petra Kleiblova, Yusuke Iwasaki, Todd A Johnson, Makoto Hirata, Yoichiro Kamatani, Yoshinori Murakami, Mikiko Endo and 10 more

Abstract read
In one paragraph

Article in JCO precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yuri TakeharaLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID 0000-0003-3285-4994
Yoshiaki UsuiLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID 0000-0001-6180-0704
Lenka StolařováCancer Cell Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.ORCID 0000-0002-0047-1502
Petra KleiblovaFirst Faculty of Medicine, Institute of Medical Biochemistry and Laboratory Diagnostics, Charles University and General University Hospital in Prague, Prague, Czech Republic.
Yusuke IwasakiLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Todd A JohnsonLaboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID 0000-0003-3377-6692
Makoto HirataDepartment of Genetic Medicine and Services, National Cancer Center Hospital, Tokyo, Japan.ORCID 0000-0002-9994-9958
Yoichiro KamataniLaboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Yoshinori MurakamiDepartment of Molecular Biology, Institute for Advanced Medical Sciences, Nippon Medical School, Tokyo, Japan.ORCID 0000-0002-2826-4396
Mikiko EndoLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Kouya ShiraishiDivision of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.ORCID 0000-0002-5821-7400
Takashi KohnoDivision of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.ORCID 0000-0002-5371-706X
Kokichi SuganoDepartment of Genetic Medicine, Kyoundo Hospital, Sasaki Foundation, Tokyo, Japan.ORCID 0000-0001-6729-366X
Koichi MatsudaLaboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.ORCID 0000-0001-7292-2686
Teruhiko YoshidaDepartment of Genetic Medicine and Services, National Cancer Center Hospital, Tokyo, Japan.ORCID 0000-0003-1607-3899
Amanda B SpurdleDivision of Genetics and Population Health, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID 0000-0003-1337-7897
Hidewaki NakagawaLaboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Libor MacurekCancer Cell Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Zdenek KleiblFirst Faculty of Medicine, Institute of Medical Biochemistry and Laboratory Diagnostics, Charles University and General University Hospital in Prague, Prague, Czech Republic.ORCID 0000-0003-2050-9667
Yukihide MomozawaLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID 0000-0001-5638-3504

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose

methodsTargeted sequencing and functional analyses of missense variants for the coding region of

resultsWe identified 77 gDVs including 36 functionally impaired missense variants.

conclusion

Indexed as

Checkpoint Kinase 2NeoplasmsAdultAgedAsia, EasternCase-Control StudiesFemaleGenetic Predisposition to DiseaseGerm-Line MutationHumansMaleMiddle AgedRisk AssessmentCheckpoint Kinase 2CHEK2 protein, human

Identifiers

PMID40893051
PMCPMC12410089

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.