Evidence map›Paper›PMID 40892929›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

AhR signaling in skin-resident CD207

Nadine Mykicki, Johannes A Eble, Heike Weighardt, Elena Gonnelli, Maria Schneeweiß, Charlotte Esser, Carsten Weishaupt, Maryam Rezaei, Irmgard Förster, Nicholas Schwab and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nadine MykickiDepartment of Immunology, University of Oldenburg, Oldenburg 26129, Germany.ORCID 0009-0008-7455-8118
Johannes A EbleInstitute for Physiological Chemistry and Biochemistry, University of Münster, Münster 48149, Germany.ORCID 0000-0001-9156-2137
Heike WeighardtLIMES-Life and Medical Science Institute, Bonn 53115, Germany.
Elena GonnelliDepartment of Dermatology, Experimental Dermatology and Immunobiology of the Skin, University of Münster, Münster 48149, Germany.ORCID 0009-0004-1882-8604
Maria SchneeweißDepartment of Dermatology, Experimental Dermatology and Immunobiology of the Skin, University of Münster, Münster 48149, Germany.ORCID 0009-0008-4511-6169
Charlotte EsserLeibniz Insitut Für Umweltmedizinische Forschung-Leibniz Research Institute for Environmental Medicine, Düsseldorf 40225, Germany.ORCID 0000-0002-2957-4636
Carsten WeishauptDepartment of Dermatology, University of Münster, Münster 48149, Germany.ORCID 0000-0003-1195-2106
Maryam RezaeiInstitute for Physiological Chemistry and Biochemistry, University of Münster, Münster 48149, Germany.
Irmgard FörsterLIMES-Life and Medical Science Institute, Bonn 53115, Germany.
Nicholas SchwabDepartment of Neurology, Institute for Translational Neurology, University of Münster, Münster 48149, Germany.ORCID 0000-0001-5494-9885
Heinz WiendlInstitute for Neurology and Neurophysiology, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.ORCID 0000-0003-4310-3432
Björn E ClausenInstitute for Molecular Medicine and Research Center for Immunotherapy (Forschungszentrum Informatik), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz 55131, Germany.ORCID 0000-0002-2484-7842
Sven G Meuth *Department of Neurology, Heinrich-Heine University Düsseldorf, Düsseldorf 40225, Germany.ORCID 0000-0003-2571-3501
Karin Loser *Department of Immunology, University of Oldenburg, Oldenburg 26129, Germany.ORCID 0000-0002-0007-0936

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental stimuli, including the exposure to ultraviolet (UV)-B light, are known to play a role in the modulation of immune-mediated mechanisms in multiple sclerosis (MS). In experimental autoimmune encephalomyelitis (EAE), we have shown that UV-B irradiation ameliorates disease outcome by regulatory T cells (Treg) expansion. Moreover, the UV-B-mediated induction of Treg numbers was also observed in MS. The aryl hydrocarbon receptor (AhR) can be activated by environmental factors including UV-B-induced photoproducts of tryptophan. Thus, we investigated the role of AhR during the transmission of UV-B irradiation. Therefore, wild-type (WT) and AhR-deficient mice (AhR

Indexed as

Basic Helix-Loop-Helix ProteinsEncephalomyelitis, Autoimmune, ExperimentalLectins, C-TypeReceptors, Aryl HydrocarbonSignal TransductionSkinUltraviolet RaysAnimalsAntigen-Presenting CellsFemaleMiceMice, Inbred C57BLMice, KnockoutMultiple SclerosisT-Lymphocytes, RegulatoryAhr protein, mouseBasic Helix-Loop-Helix ProteinsLectins, C-TypeReceptors, Aryl Hydrocarbonaryl hydrocarbon receptorcutaneous dendritic cellsexperimental autoimmune encephalomyelitismultiple sclerosisUV-B

Identifiers

PMID40892929
PMCPMC12435267

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.