Evidence map›Paper›PMID 40892928›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The RNA-binding protein TRIM71 is essential for hearing in humans and mice and times auditory sensory organ development.

Xiao-Jun Li, Charles Morgan, Phan Q Duy, Lale Evsen, Le T Hao, Roxane Machavoine, Kahina Belhous, Sylvain Ernest, Françoise Denoyelle, Cyril Mignot and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Xiao-Jun LiThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Charles MorganThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0002-8766-0954
Phan Q DuyDepartment of Neuroscience and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510.
Lale EvsenThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0009-0003-2417-3598
Le T HaoDepartment of Neurosurgery, Yale University School of Medicine, New Haven, CT 06510.
Roxane MachavoineCentre de Référence Surdités Génétiques, Service de Médecine génomique des Maladies Rares, UF Morphogenèse et Développement, Hôpital Necker, Assistance Publique-Hopitaux de Paris, Université Paris Cité, Paris F-75015, France.
Kahina BelhousService de Radiologie Pédiatrique, Hôpital Necker, Assistance Publique-Hopitaux de Paris, Université Paris Cité, Paris F-75015, France.
Sylvain ErnestINSERM UMR1163, Institut Imagine, Université Paris Cité, Paris F-75015, France.
Françoise DenoyelleService d'Oto-rhino-laryngologie Pédiatrique et de Chirurgie Cervico Faciale, Hôpital Necker, Assistance Publique-Hopitaux de Paris, Université Paris Cité, Paris F-75015, France.
Cyril MignotDépartement de Génétique, Groupe Hospitalier Pitié-Salpêtrière and Hôpital Trousseau and Centre de Référence Maladies Rares Déficiences Intellectuelles de Causes Rares, Assistance Publique-Hopitaux de Paris Sorbonne Université, Paris F-75015, France.
Frederic BrioudeINSERM, Centre de Recherche Saint-Antoine, Assistance Publique-Hopitaux de Paris, Hôpital Trousseau, Sorbonne Université, Paris F-75012, France.
Marine ParodiService d'Oto-rhino-laryngologie Pédiatrique et de Chirurgie Cervico Faciale, Hôpital Necker, Assistance Publique-Hopitaux de Paris, Université Paris Cité, Paris F-75015, France.
Lin LiFrontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.ORCID 0009-0007-8284-6331
He HuangThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Prathamesh T Nadar PonniahThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Waldemar KolanusMolecular Immunology and Cell Biology, Life and Medical Sciences Institute, University of Bonn, Bonn 53115, Germany.
Kristopher T KahleDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.ORCID 0000-0002-5922-7547
Sandrine MarlinCentre de Référence Surdités Génétiques, Service de Médecine génomique des Maladies Rares, UF Morphogenèse et Développement, Hôpital Necker, Assistance Publique-Hopitaux de Paris, Université Paris Cité, Paris F-75015, France.
Angelika DoetzlhoferThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0002-7424-2112

Funding

Human Genetics and Molecular Mechanisms of Vein of Galen Aneurysmal MalformationR01NS117609 · NINDS · YALE UNIVERSITY · PI Titus Jonathon Boggon, Kristopher T. Kahle · 2020 to 2026
$3.3M
The function of LIN28B and follistatin in supporting cell reprogramming and hair cell regeneration in the murine cochleaR01DC019359 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI ANGELIKA DOETZLHOFER · 2022 to 2026
$2.5M
Modulation of Choroid Plexus Immuno-secretory Function to Restore Cerebrospinal Fluid Homeostasis in HydrocephalusR01NS109358 · NINDS · YALE UNIVERSITY · PI Kristopher T. Kahle · 2018 to 2026
$2.4M
Cellular and Molecular Mechanisms of Neurotoxicity and Cognitive Deficits Due to Hyperphosphorylated TauF32AG089892 · NIA · UNIVERSITY OF VIRGINIA · PI PHAN, DUY · 2024 to 2025
$165k
The role of supporting cell de-differentiation in cochlear hair cell regenerationF31DC020882 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI MORGAN, CHARLES · 2022 to 2024
$143k
Agence Nationale de la Recherche (ANR) ANR-10-IAHU-01David M. Rubenstein Fund for Hearing Research internal fundingHHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) RO1NS109358HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) RO1NS117609HHS | NIH | National Institute on Aging (NIA) F32AG089892HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) DC019359HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) DC020882National Natural Science Fund for Excellent Young Scientists Fund Program GYKP045Natural Science Basic Research Plan in Shaanxi Province of China 2024JC-ZDXM-43NIA NIH HHS F32 AG089892NIDCD NIH HHS F31 DC020882NIDCD NIH HHS R01 DC019359NINDS NIH HHS R01 NS109358NINDS NIH HHS R01 NS117609
6 · The paper itself

Abstract

The RNA-binding protein TRIM71 is essential for brain development, and recent genetic studies in humans have identified

Indexed as

HearingHearing LossRNA-Binding ProteinsTripartite Motif ProteinsUbiquitin-Protein LigasesAnimalsCell DifferentiationCochleaEar, InnerGene Expression Regulation, DevelopmentalHair Cells, AuditoryHumansMiceMice, KnockoutRNA-Binding ProteinsTripartite Motif ProteinsUbiquitin-Protein Ligasesauditorydevelopmental timinghair cell differentiationhearing lossTrim71

Identifiers

PMID40892928
PMCPMC12435228

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.