Evidence map›Paper›PMID 40892921›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Metabolic rewiring of isoniazid sensitivity in

Erin R Wang, Kevin Cho, Gregory A Harrison, Stephanie R Smelyansky, Vijay Soni, Asya Smirnov, Samuel R McKee, George S Ghabrial, Kelly N Flentie, Wandy Beatty and 11 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Erin R WangDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110.ORCID 0000-0002-9163-6316
Kevin ChoDepartment of Chemistry, Washington University in St. Louis, Saint Louis, MO 63110.ORCID 0000-0002-3041-3506
Gregory A HarrisonDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110.ORCID 0000-0002-6050-1312
Stephanie R SmelyanskyDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0009-0004-2930-2907
Vijay SoniDepartment of Medicine, Weill Cornell Medicine, New York, NY 10021.ORCID 0000-0002-3395-7429
Asya SmirnovDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110.ORCID 0000-0003-4767-1680
Samuel R McKeeDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110.
George S GhabrialDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110.ORCID 0009-0000-5057-529X
Kelly N FlentieDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110.
Wandy BeattyDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110.
Boatema Ofori-AnyinamCenter for Emerging and Re-emerging Pathogens, Public Health Research Institute, Rutgers New Jersey Medical School, Newark NJ 07103.
Souvik SarkarDepartment of Chemistry, Umeå University, Umeå SE-90187, Sweden.
Thomas HurtauxDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110.ORCID 0000-0002-1633-5329
Liza LozaDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110.
Fredrik AlmqvistDepartment of Chemistry, Umeå University, Umeå SE-90187, Sweden.ORCID 0000-0002-0504-4446
Tamara L DoeringDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110.ORCID 0000-0002-5179-7393
Jason H YangCenter for Emerging and Re-emerging Pathogens, Public Health Research Institute, Rutgers New Jersey Medical School, Newark NJ 07103.ORCID 0000-0003-0921-4657
Laura L KiesslingDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0001-6829-1500
Kyu Y RheeDepartment of Medicine, Weill Cornell Medicine, New York, NY 10021.
Gary J PattiDepartment of Chemistry, Washington University in St. Louis, Saint Louis, MO 63110.
Christina L StallingsDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110.ORCID 0000-0002-2747-5618

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
Infectious Diseases/Basic Microbial Pathogenic MechanismsT32AI007172 · NIAID · WASHINGTON UNIVERSITY · PI Daniel E. Goldberg, JENNIFER A PHILIPS · 1985 to 2026
$13.0M
Developing Metabolomic Technologies to Advance Environmental Exposure AnalysisR35ES028365 · NIEHS · WASHINGTON UNIVERSITY · PI PATTI, GARY J · 2017 to 2024
$5.9M
The Chemistry and Biology of Galactofuranose-Containing GlycansR01AI126592 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Laura L Kiessling · 2017 to 2026
$5.2M
Genetic, Metabolic and Regulatory Control of MIC and Relapse in M. tuberculosisR01AI146194 · NIAID · UNIVERSITY OF WASHINGTON · PI ALLAND, DAVID, SHERMAN, DAVID R · 2020 to 2024
$4.1M
Chemical disarming of drug resistance in Mycobacterium tuberculosisR01AI134847 · NIAID · WASHINGTON UNIVERSITY · PI ALMQVIST, FREDRIK, STALLINGS, CHRISTINA LEIGH · 2018 to 2021
$2.7M
CRYPTOCOCCAL GLYCAN SYNTHESISR01AI135012 · NIAID · WASHINGTON UNIVERSITY · PI DOERING, TAMARA L · 2018 to 2022
$2.5M
Erling-Persson Foundation NAJoint Programming Initiative on Anti-microbial Resistance 2018-00969Kempestiftelserna (Kempe Foundations) SMK-1755NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI126592NIAID NIH HHS R01 AI134847NIAID NIH HHS R01 AI135012NIAID NIH HHS R01 AI146194NIAID NIH HHS T32 AI007172NIEHS NIH HHS R35 ES028365NSF | National Science Foundation Graduate Research Fellowship Program (GRFP) 1745302 and 2141064NSF | National Science Foundation Graduate Research Fellowship Program (GRFP) DGE-1745038Swedish Research Council 2018-04589 and 2021-05040 J
6 · The paper itself

Abstract

Isoniazid (INH) inhibits mycolic acid synthesis in

Indexed as

Anti-Bacterial AgentsIsoniazidMycobacterium tuberculosisCitric Acid CycleDrug Resistance, BacterialGluconeogenesisHumansPeptidoglycanPyruvic AcidTuberculosisValineAnti-Bacterial AgentsIsoniazidPeptidoglycanPyruvic AcidValinecell envelopeisoniazidmetabolismMycobacterium tuberculosispeptidoglycan

Identifiers

PMID40892921
PMCPMC12435213

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.