ArticleProceedings of the National Academy of Sciences of the United States of America2025
HLA-B*15:01-positive severe COVID-19 patients lack CD8
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
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Who cites it
3 citing papers in PubMed.
- HLA-B*15:01 and HLA-DRB1*07:01 as novel markers of acute GVHD in pediatric HSCT.Bone marrow transplantation · 2026Article
- Different risks, same causes: educational attainment influences when, not from what, we die.European journal of epidemiology · 2026Article
- Antigen specificity, not tissue compartment, determines clonal sharing among respiratory tract CD8Immunology and cell biology · 2026Article
Corrections and comments
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Authors and funding
60 authors.
Louise C RowntreeDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.ORCID 0000-0002-0649-5089
Lilith F AllenDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Ruth R HagenDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Hayley A McQuiltenDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Ahmed A QuadeerDepartment of Electronic and Computer Engineering, School of Engineering, Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, Hong Kong, China.
Priyanka ChaurasiaInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0002-3755-159X
Prathanporn KaewpreedeeHKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.
Kelly W K LeeHKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.
Carolyn A CohenHKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.
Jan PetersenInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Dene R LittlerInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0001-5904-1905
Jennifer R HabelDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Wuji ZhangDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Samuel M S ChengDivision of Public Health Laboratory Sciences, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.ORCID 0000-0001-7293-2331
Ken Ka Pang ChanDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.
Janette S Y KwokDivision of Transplantation and Immunogenetics, Department of Pathology, Queen Mary Hospital, Hong Kong Special Administrative Region, Hong Kong, China.
Kathy S M LeungThe Hong Kong Jockey Club Global Health Institute, Hong Kong Special Administrative Region, Hong Kong, China.ORCID 0000-0003-4777-388X
Joseph T WuThe Hong Kong Jockey Club Global Health Institute, Hong Kong Special Administrative Region, Hong Kong, China.ORCID 0000-0002-3155-5987
Cheuk-Kwong LeeThe Hong Kong Jockey Club Global Health Institute, Hong Kong Special Administrative Region, Hong Kong, China.
Jane DaviesMenzies School of Health Research, Darwin, NT 0810, Australia.
Pia S PannarajDivision of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, CA 90027.
E Kaity AllenDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Paul G ThomasDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105.ORCID 0000-0001-7955-0256
Shidan TosifInfection and Immunity, Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia.
Nigel W CrawfordInfection and Immunity, Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia.
Martha LappasDepartment of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, VIC 3010, Australia.
Irani ThevarajanDepartment of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Sharon R LewinDepartment of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Stephen J KentDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.ORCID 0000-0002-8539-4891
Jennifer A JunoDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.ORCID 0000-0002-9072-1017
Katherine A BondDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Deborah A WilliamsonVictorian Infectious Diseases Service, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Natasha E HolmesDepartment of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Olivia C SmibertDepartment of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC 3084, Australia.
Claire L GordonDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Jason A TrubianoDepartment of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Tom C KotsimbosDepartment of Respiratory Medicine, The Alfred Hospital, Melbourne, VIC 3004, Australia.
Allen C ChengSchool of Public Health and Preventive Medicine, Monash University, Clayton, VIC 3004, Australia.
Claudia EfstathiouNational Heart and Lung Institute, Imperial College London, London SW3 6LY, United Kingdom.
Lance TurtleInstitute of Infection, Ecological and Veterinary Sciences, University of Liverpool & Liverpool University Hospital National Health Service Foundation Trust, Wirral CH64 7TE, United Kingdom.
Ryan S ThwaitesNational Heart and Lung Institute, Imperial College London, London SW3 6LY, United Kingdom.
Christopher E BrightlingInstitute for Lung Health, Leicester NIHR BRC, University of Leicester, Leicester LE1 7RH, United Kingdom.
PHOSP-COVID Collaborative Group
Jamie RossjohnInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0002-2020-7522
Matthew R McKayDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Jinmin TianNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
William Jun LiuNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
George Fu GaoNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.ORCID 0000-0002-3869-615X
Jianqing XuShanghai Public Health Clinical Centre and Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai 201508, China.
Kyuto SoneharaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
Ken J IshiiLaboratory of Adjuvant Innovation, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Saito Asagi, Ibaraki 567-0085, Osaka, Japan.ORCID 0000-0002-6728-3872
Ho NamkoongDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo 160-8582, Japan.
Yukinori OkadaDepartment of Genome Informatics, Graduate School of Medicine, University of Tokyo, Tokyo 113-8654, Japan.
Malik PeirisHKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.ORCID 0000-0001-8217-5995
David S C HuiDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.
Leo L M PoonHKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.ORCID 0000-0002-9101-7953
Peter C Doherty *Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Thi H O Nguyen *Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.ORCID 0000-0002-9294-7693
Sophie A Valkenburg *Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.ORCID 0000-0002-0768-9926
Katherine Kedzierska *Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.ORCID 0000-0001-6141-335X
Funding
Household Respiratory Virus SARS-CoV-2 Transmission and Immunity Sub-Study (HRTS)U01AI144616 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GORDON, AUBREE L, THOMAS, PAUL G. · 2019 to 2025
$43.7MFederal Government | DHAC | National Health and Medical Research Council (NHMRC) 1173871NIAID NIH HHS U01 AI144616
Abstract
Understanding host factors driving asymptomatic versus severe disease outcomes is of key importance if we are to control emerging and re-emerging viral infections. HLA-B*15:01 has been associated with asymptomatic SARS-CoV-2 infection in nonhospitalized individuals of European ancestry, with protective immunity attributed to preexisting cross-reactive CD8
Indexed as
CD8-Positive T-LymphocytesCOVID-19SARS-CoV-2AdultAgedFemaleHumansMaleMiddle AgedSpike Glycoprotein, CoronavirusSpike Glycoprotein, CoronavirusCD8+ T cellsCOVID-19HLA-B*15:01severe diseaseT cell receptors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.