Evidence map›Paper›PMID 40892912›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Structural insights into the substrate uptake and inhibition of the human creatine transporter (hCRT).

Xinyi Yuan, Jian Yin, Chang Liu, Xudong Chen, Meiying Chen, Yixue Wang, Zi Yang, Yue Wang, Li Jiang, Niyun Zhou and 8 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Xinyi Yuan *Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0009-0007-3574-8018
Jian Yin *Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Chang Liu *Beijing Life Science Academy, Beijing 102209, China.
Xudong Chen *Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.ORCID 0000-0002-2989-5608
Meiying ChenMinistry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Yixue WangMinistry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.ORCID 0000-0001-5254-5940
Zi YangTechnology Center for Protein Research, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Yue WangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou 311121, China.
Li JiangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0000-0002-5628-2727
Niyun ZhouMinistry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Xiaojuan WangDepartment of Endocrinology, Genetics and Metabolism, National Center for Children's Health, Beijing Children's Hospital Capital Medical University, Beijing 100045, China.
Botong LiuMinistry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Zhaoqi MaCollege of Biological Science, China Agricultural University, Beijing 100083, China.ORCID 0009-0007-3566-9176
Kaiyan WangNational Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, School of Stomatology, The Fourth Military Medical University, Xi'an, Shanxi 710032, China.
Hongen LiDepartment of Ophthalmology, The Chinese People's Liberation Army General Hospital & The Chinese People's Liberation Army Medical School, Beijing 100039, China.ORCID 0000-0002-4885-6110
Sensen ZhangMinistry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.ORCID 0000-0001-8827-3959
Yongfeng ShangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0000-0001-5050-7625
Maojun YangMinistry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.ORCID 0000-0002-6798-3094

Funding

MOST | National Key Research and Development Program of China (NKPs) 2022YFA1302701MOST | National Natural Science Foundation of China (NSFC) 32030056
6 · The paper itself

Abstract

Creatine plays a vital role in cellular energy production and adenosine triphosphate (ATP) homeostasis and has also been identified as a neurotransmitter in the mammalian brain. Creatine is transported into cells by the human creatine transporter (hCRT) (SLC6A8), an Na

Indexed as

CreatineMembrane Transport ProteinsNerve Tissue ProteinsPlasma Membrane Neurotransmitter Transport ProteinsBrain Diseases, Metabolic, InbornCryoelectron MicroscopyHumansModels, MolecularX-Linked Intellectual DisabilityCreatinecreatine transporterMembrane Transport ProteinsNerve Tissue ProteinsPlasma Membrane Neurotransmitter Transport ProteinsSLC6A8 protein, humancompetitive inhibitionhuman creatine transportersubstrate uptake

Identifiers

PMID40892912
PMCPMC12435270

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.