Evidence map›Paper›PMID 40892700›Full record

ArticlePhysiological reports2025

Long COVID and chronic fatigue syndrome/myalgic encephalitis share similar pathophysiologic mechanisms of exercise limitation.

Swathi Jothi, Michael Insel, Guido Claessen, Saad Kubba, Erin J Howden, Sergio Ruiz-Carmona, Todd Levine, Franz P Rischard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. An Overview of Severe Myalgic Encephalomyelitis.Journal of clinical medicine · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Swathi JothiDivision of Pulmonary, Critical Care, Sleep, and Allergy Medicine, University of Arizona, Tucson, Arizona, USA.
Michael InselDivision of Pulmonary, Critical Care, Sleep, and Allergy Medicine, University of Arizona, Tucson, Arizona, USA.
Guido ClaessenDepartment of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
Saad KubbaSarver Heart Center, University of Arizona, Tucson, Arizona, USA.
Erin J HowdenBaker Heart and Diabetes Institute, Melbourne, Australia.
Sergio Ruiz-CarmonaBaker Heart and Diabetes Institute, Melbourne, Australia.
Todd LevineHonor Health Neurology, Scottsdale, Arizona, USA.
Franz P RischardDivision of Pulmonary, Critical Care, Sleep, and Allergy Medicine, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0002-6861-8304

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-acute sequelae of SARS-CoV-2 (PASC or "long COVID") and chronic fatigue syndrome/myalgic encephalitis (CFS/ME) share symptoms such as exertional dyspnea. We used exercise oxygen pathway analysis, comprising six parameters of oxygen transport and utilization, to identify limiting mechanisms in both conditions. Invasive cardiopulmonary exercise testing was performed on 15 PASC patients, 11 CFS/ME patients, and 11 controls. We evaluated the contributions of alveolar ventilation (V̇a), lung diffusion capacity (D

Indexed as

COVID-19ExerciseExercise ToleranceFatigue Syndrome, ChronicAdultExercise TestFemaleHumansMaleMiddle AgedMuscle, SkeletalOxygen ConsumptionPost-Acute COVID-19 SyndromeSARS-CoV-2chronic fatigue syndromeexerciselong‐COVIDmyalgic encephalitispost‐acute sequelae of SARS Co‐V2

Identifiers

PMID40892700
PMCPMC12404247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.