Evidence map›Paper›PMID 40892693›Full record

ArticleNeonatology2025

Cerebral Oxygenation Pattern during Therapeutic Hypothermia after Perinatal Asphyxia: A Single Center Cohort Study.

Thomas Alderliesten, Corline E J Parmentier, Manon J N L Benders, Linda S de Vries, Daniel C Vijlbrief, Jeroen Dudink, Maria-Luisa Tataranno, Petra M A Lemmers, Floris Groenendaal, Frank van Bel

Abstract read
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In one paragraph

Article in Neonatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Thomas AlderliestenDepartment of Neonatology, Wilhelmina Children's Hospital and UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Corline E J ParmentierDepartment of Neonatology, Wilhelmina Children's Hospital and UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Manon J N L BendersDepartment of Neonatology, Wilhelmina Children's Hospital and UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Linda S de VriesDepartment of Neonatology, Wilhelmina Children's Hospital and UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Daniel C VijlbriefDepartment of Neonatology, Wilhelmina Children's Hospital and UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Jeroen DudinkDepartment of Neonatology, Wilhelmina Children's Hospital and UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Maria-Luisa TatarannoDepartment of Neonatology, Wilhelmina Children's Hospital and UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Petra M A LemmersDepartment of Neonatology, Wilhelmina Children's Hospital and UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Floris GroenendaalDepartment of Neonatology, Wilhelmina Children's Hospital and UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands, f.groenendaal@umcutrecht.nl.
Frank van BelDepartment of Neonatology, Wilhelmina Children's Hospital and UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInvestigation the association between cerebral oxygenation and short-term adverse outcome in asphyxiated infants with hypoxic-ischemic encephalopathy (HIE) during therapeutic hypothermia (TH).

methodsNear infrared spectroscopic-derived cerebral oxygen saturation (rScO

results292 infants (mean ± 1 SD: GA 39.4 ± 1.9 weeks; BW 3,442 ± 621 g; median [IQR] 5-min Apgar score 4 [3]) were eligible. According to the Sarnat staging, HIE was mild, moderate, or severe in 77, 148, and 67 infants. Adverse short-term outcome/death occurred in 0, 39 (26.4%), and 67 (100%) infants in mild, moderate, and severe HIE groups. Severe HIE infants had higher rScO DISCUSSION: High cerebral oxygen saturation during TH is associated with adverse short-term outcome. This knowledge may contribute to early counseling and decision-making. Combination with early blood lactate levels strengthened this association. Simultaneous NO-ventilation may confound this association.

Indexed as

Asphyxia NeonatorumBrainHypothermia, InducedHypoxia-Ischemia, BrainOxygenOxygen SaturationApgar ScoreCohort StudiesFemaleGestational AgeHumansInfant, NewbornMagnetic Resonance ImagingMaleSpectroscopy, Near-InfraredOxygenCerebral oxygenationShort-term outcomeTherapeutic hypothermia

Identifiers

PMID40892693
PMCPMC12668717

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.