Evidence map›Paper›PMID 40892532›Full record

Trial reportClinical transplantation2025

Ultrasound-Guided Modified Thoracoabdominal Nerve Block Through Perichondrial Approach for Postoperative Analgesia Management in Living Liver Donors: A Randomized, Prospective, Controlled Study.

Hande Gungor, Ayşe Ince, Bahadir Ciftci, Birzat Emre Gölboyu, Mert Asici, Pelin Karaaslan, Tumay Uludag Yanaral

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06300372 (Ultrasonography-Guided Bilateral Modified Thoracoabdominal Nerve Plane Block With Perichondrial Approach), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06300372 nacompletednot on this map

Ultrasonography-Guided Bilateral Modified Thoracoabdominal Nerve Plane Block With Perichondrial Approach (M-TAPA) For Postoperative Pain Management In Living Liver Donors: Randomized Controlled Study.

TypeinterventionalSponsorIstanbul Medipol University HospitalRan2024 to 2025Enrolled50ConditionsLiver Failure, Acute Postoperative PainArmsM-TAPA plane block, Postoperative pain management
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Abdominal Organ Transplantation: Noteworthy Literature in 2025.Seminars in cardiothoracic and vascular anesthesia · 2026
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hande GungorDepartment of Anesthesiology and Reanimation, Istanbul Medipol University, Istanbul, Turkey.
Ayşe InceDepartment of Anesthesiology and Reanimation, Istanbul Medipol University, Istanbul, Turkey.
Bahadir CiftciDepartment of Anesthesiology and Reanimation, Istanbul Medipol University, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-3245-6614
Birzat Emre GölboyuDepartment of Anesthesiology and Reanimation, Katip Çelebi University, Izmir, Turkey.
Mert AsiciDepartment of Anesthesiology and Reanimation, Istanbul Medipol University, Istanbul, Turkey.
Pelin KaraaslanDepartment of Anesthesiology and Reanimation, Istanbul Medipol University, Istanbul, Turkey.
Tumay Uludag YanaralDepartment of Anesthesiology and Reanimation, Istanbul Medipol University, Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOptimal postoperative pain management in living donor hepatectomy remains challenging, with conventional methods showing limitations. This study evaluated the efficacy and safety of ultrasound-guided modified thoracoabdominal nerve block through a perichondrial approach (M-TAPA) compared to conventional pain management in living donor hepatectomy patients.

methodsIn this prospective, randomized, controlled, single-blind study conducted between April 2024 and January 2025, 50 ASA I-II patients undergoing living donor right hepatectomy were randomly allocated to either the M-TAPA group (n = 25, receiving ultrasound-guided M-TAPA block plus standard analgesia) or the Control group (n = 25, receiving conventional pain management only). The primary outcome was postoperative opioid consumption during the first 48 h. Secondary outcomes included pain scores, rescue analgesia requirements, and complications.

resultsThe M-TAPA group showed significantly lower median total fentanyl consumption (p = 0.002) and reduced need for rescue analgesia (p = 0.011) compared to the Control group. Both static and dynamic Numeric Rating Scale pain scores were significantly lower in the M-TAPA group across all time points (p < 0.001). Although the M-TAPA group showed a trend toward reduced nausea incidence (p = 0.066), other side effects were comparable between groups. No M-TAPA block-related complications were reported.

conclusionsUltrasound-guided M-TAPA block provides effective postoperative pain management in living donor hepatectomy, demonstrating significant reductions in opioid consumption and pain scores without increasing complications. These findings suggest MTAPA could be a valuable component of enhanced recovery protocols in living donor liver transplantation programs.

trial registrationClinicalTrials.gov identifier: NCT06300372.

Indexed as

HepatectomyLiver TransplantationLiving DonorsNerve BlockPain ManagementPostoperative PainUltrasonography, InterventionalAdultFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisProspective StudiesSingle-Blind Methodliver transplantationliving donor hepatectomyM‐TAPA blockpain managementregional anesthesiaultrasonography

Identifiers

PMID40892532
PMCPMC12404281

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.