Evidence map›Paper›PMID 40892527›Full record

ArticleSubstance use & misuse2026

Reach of Community-Selected Strategies to Reduce Opioid-Related Overdose Deaths in the HEALing Communities Study.

Megan E Hall, LaShawn Glasgow, JaNae Holloway, Rouba A Chahine, Jill Davis, Miriam T H Harris, Hannah K Knudsen, Jessica L Neufeld, Emmanuel Oga, David W Lounsbury and 10 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Substance use & misuse, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04111939 (HEALing Communities Study), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04111939 nacompletednot on this map

HEALing Communities Study: Developing and Testing an Integrated Approach to Address the Opioid Crisis

TypeinterventionalSponsorRTI InternationalRan2019 to 2025Enrolled67ConditionsOpioid Use Disorder (OUD)ArmsCommunities That HEAL, Wait-list control
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Megan E HallRTI International, Research Triangle Park, North Carolina, USA.
LaShawn GlasgowRTI International, Research Triangle Park, North Carolina, USA.ORCID 0000-0003-3336-7039
JaNae HollowayRTI International, Research Triangle Park, North Carolina, USA.
Rouba A ChahineRTI International, Research Triangle Park, North Carolina, USA.
Jill DavisThe Ohio State University, Columbus, Ohio, USA.
Miriam T H HarrisBoston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Hannah K KnudsenUniversity of Kentucky, Lexington, Kentucky, USA.
Jessica L NeufeldColumbia University, New York, New York, USA.
Emmanuel OgaRTI International, Research Triangle Park, North Carolina, USA.
David W LounsburyAlbert Einstein College of Medicine, Bronx, New York, USA.
Nasim SabounchiCUNY Graduate School of Public Health and Health Policy, New York, New York, USA.
Alissa DavisColumbia University, New York, New York, USA.
Marissa SmithThe Ohio State University, Columbus, Ohio, USA.
Rachel P ChaseThe Ohio State University, Columbus, Ohio, USA.
Sylvia A EllisonThe Ohio State University, Columbus, Ohio, USA.
Judy HarnessThe Ohio State University, Columbus, Ohio, USA.
Hilary L SurrattUniversity of Kentucky, Lexington, Kentucky, USA.
Sharon L WalshUniversity of Kentucky, Lexington, Kentucky, USA.
Peace Julie NakayimaUniversity of Kentucky, Lexington, Kentucky, USA.
Redonna ChandlerNational Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland, USA.

Funding

MassHEAL - Reducing overdose deaths by 40% (2019-2023)UM1DA049412 · NIDA · BOSTON MEDICAL CENTER · PI SAMET, JEFFREY H. · 2019 to 2023
$82.9M
Kentucky CAN HEAL (Communities and Networks Helping End Addiction Long-term)UM1DA049406 · NIDA · UNIVERSITY OF KENTUCKY · PI WALSH, SHARON L. · 2019 to 2022
$81.7M
CHASE: An Innovative County-Level Public Health Response to the Opioid Epidemic in New York StateUM1DA049415 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI EL-BASSEL, NABILA, GILBERT, LOUISA · 2019 to 2023
$77.3M
Optimizing HEALing in Ohio Communities (OHiO)-Health Equity SupplementUM1DA049417 · NIDA · OHIO STATE UNIVERSITY · PI FREISTHLER, BRIDGET J, WINHUSEN, T JOHN · 2019 to 2023
$66.3M
HEALing Communities Study Health Equity ResearchUM1DA049394 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI GLASGOW, LASHAWN, OGA, EMMANUEL AJA · 2019 to 2023
$40.6M
Training Program on HIV and Substance Use in the Criminal Justice SystemT32DA037801 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Nabila El-Bassel, Lisa R Metsch · 2014 to 2026
$5.7M
NIDA NIH HHS T32 DA037801NIDA NIH HHS UM1 DA049394NIDA NIH HHS UM1 DA049406NIDA NIH HHS UM1 DA049412NIDA NIH HHS UM1 DA049415NIDA NIH HHS UM1 DA049417
6 · The paper itself

Abstract

introductionDespite recent declines, the U.S. opioid overdose crisis persists. The HEALing Communities Study (HCS) aimed to reduce opioid overdose deaths through community-level adoption of evidence-based practices (EBPs), including overdose education and naloxone distribution (OEND) and medications for opioid use disorder (MOUD). This paper describes the reach of OEND and MOUD strategies implemented by the 33 HCS wait-list control communities.

methodsWe conducted descriptive statistical analysis of reach data collected from July 2022 through December 2023 to (1) summarize overall EBP implementation and reach and (2) compare the demographic representation of individuals reached to community demographic population estimates.

resultsCommunities implemented 474 EBPs (251 OEND, 223 MOUD), reporting an average reach of 16,482 individuals monthly. For OEND, percent reached exceeded community population representation for individuals aged 18-34 years (40% vs 31%) and 35-54 years (41% vs 31%) and non-Hispanic Black individuals (20% vs 15%). For MOUD, percent reached exceeded the opioid use disorder population representation for individuals aged 35-54 years (58% vs 52%) and non-Hispanic White individuals (88% vs 80%); however, there was lower representation for individuals aged 18-34 years (28% vs 38%) and non-Hispanic Black individuals (6% vs 13%). Distributions by sex were comparable for OEND and MOUD.

conclusionsFindings signal the promise of community-engaged interventions to reach diverse groups with OEND and reflect the challenges of overcoming longstanding barriers to MOUD access. This work provides practical examples for monitoring the reach of EBPs across multiple research sites and communities and for assessing representativeness, a valuable marker of equity. Trial Registration: Clinical Trials.gov http://www.clinicaltrials.gov: Identifier: NCT04111939.

Indexed as

Drug OverdoseEvidence-Based PracticeNaloxoneOpiate OverdoseOpioid-Related DisordersAdolescentAdultFemaleHumansMaleMiddle AgedMulticenter Studies as TopicNarcotic AntagonistsRandomized Controlled Trials as TopicUnited StatesYoung AdultNaloxoneNarcotic Antagonistscommunity interventionimplementation scienceOpioidsoverdosereach

Identifiers

PMID40892527
PMCPMC12466881

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.