Evidence map›Paper›PMID 40892495›Full record

ArticleBiomaterials science2025

Development of a bioactive, piezoelectric PVDF-TrFE scaffold with evaluation of tissue reaction for potential in nerve repair.

Andrew E Bryan, Maksym Krutko, Sandra Rebholz, Lindsey E Marquez, Emma Busch, Kevin Dong, Sarah K Pixley, Melanie T Cushion, Leyla Esfandiari, Greg M Harris

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrew E BryanDepartment of Chemical and Environmental Engineering, College of Engineering and Applied Sciences, University of Cincinnati, Cincinnati, OH, USA 45221. gregory.harris@uc.edu.
Maksym KrutkoDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, University of Cincinnati, Cincinnati, OH, USA 45221.
Sandra RebholzDepartment of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH, USA 45267.
Lindsey E MarquezDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, University of Cincinnati, Cincinnati, OH, USA 45221.
Emma BuschDepartment of Chemical and Environmental Engineering, College of Engineering and Applied Sciences, University of Cincinnati, Cincinnati, OH, USA 45221. gregory.harris@uc.edu.
Kevin DongDepartment of Chemical and Environmental Engineering, College of Engineering and Applied Sciences, University of Cincinnati, Cincinnati, OH, USA 45221. gregory.harris@uc.edu.
Sarah K PixleyDepartment of Pharmacology, Physiology, and Neurobiology, College of Medicine, University of Cincinnati, Cincinnati, OH, USA 45267.ORCID http://orcid.org/0000-0003-2713-4263
Melanie T CushionDepartment of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH, USA 45267.
Leyla EsfandiariDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, University of Cincinnati, Cincinnati, OH, USA 45221.ORCID http://orcid.org/0000-0001-6851-1198
Greg M HarrisDepartment of Chemical and Environmental Engineering, College of Engineering and Applied Sciences, University of Cincinnati, Cincinnati, OH, USA 45221. gregory.harris@uc.edu.ORCID http://orcid.org/0000-0001-5594-9780

Funding

Developing multi-cue piezoelectric PVDF-TrFE biomaterials for peripheral nerve repairR01NS134804 · NINDS · UNIVERSITY OF CINCINNATI · PI Greg M Harris · 2024 to 2026
$1.3M
BLRD VA IK6 BX005232NINDS NIH HHS R01 NS134804
6 · The paper itself

Abstract

Current biomaterials for trauma-associated tissue repair often fail to recapitulate the complex signaling environment required for effective integration and regeneration, particularly in modulating immune responses post-implantation. To address these limitations, we developed a multi-cue electrospun scaffold incorporating physiologically relevant chemical, electrical, and physical signals. Using blend electrospinning, we functionalized poly(vinylidene fluoride-trifluoroethylene) (PVDF-TrFE) with cell-secreted, decellularized extracellular matrix (dECM) to enhance cellular responses and limit foreign body reactions. The resulting scaffolds were systematically characterized

Indexed as

Biocompatible MaterialsHydrocarbons, FluorinatedNerve RegenerationPeripheral Nerve InjuriesPolyvinylsTissue ScaffoldsAnimalsCell AdhesionExtracellular MatrixFluorocarbon PolymersMaleRatsRats, Sprague-DawleySchwann CellsTissue EngineeringBiocompatible MaterialsFluorocarbon PolymersHydrocarbons, Fluorinatedpolyvinylidene fluoridePolyvinylsvinylidene fluoride-trifluoroethylene copolymer

Identifiers

PMID40892495
PMCPMC12404288

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.