ArticleCell biochemistry and biophysics2026
A New Direction for Delaying Intervertebral Disc Degeneration: Resveratrol Inhibits Ferroptosis in Nucleus Pulposus Cells.
Article in Cell biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
8 authors.
Funding
Abstract
Intervertebral disc degeneration (IVDD), characterized by lower back pain, is a prevalent chronic orthopedic disease imposing significant physical and economic burdens. However, the molecular mechanisms of IVDD remain insufficiently explored, hindering clinical guidance. This study aimed to identify key targets of IVDD via bioinformatics, providing new therapeutic directions. Gene expression profiles GSE34095 and GSE150408 were retrieved from public databases, and IVDD-related gene datasets were obtained from GeneCards and CTD. Protein-protein interaction (PPI) networks were constructed, followed by functional enrichment analyses using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Reactome Pathway Knowledgebase (Reactome), and WikiPathways. Key genes associated with the ferroptosis pathway were screened, and the effect of resveratrol on IVDD was validated via in vitro and in vivo experiments. Enrichment analyses identified ferroptosis as the major signaling pathway in IVDD. Six key genes (Glutathione Peroxidase 4 (GPX4), Transferrin receptor (TFRC/TFR1), Solute Carrier Family 7 Member 11 (SLC7A11/xCT), Hypoxia Inducible Factor 1 Subunit Alpha Gene (HIF1A), Interleukin-6 (IL6), and Interleukin-1 Beta (IL1B)) were selected. In vitro studies showed that resveratrol inhibited ferroptosis in nucleus pulposus cells (NPCs), while in vivo experiments in rats confirmed that resveratrol alleviated IVDD by regulating ferroptosis-related genes. Molecular docking validated the binding of resveratrol to these key targets. This study demonstrates that resveratrol delays IVDD progression by inhibiting ferroptosis in NPCs, providing a novel therapeutic strategy for clinical IVDD prevention and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.