Evidence map›Paper›PMID 40892350›Full record

ArticleEsophagus : official journal of the Japan Esophageal Society2025

Impact of surgical approaches on postoperative body weight and nutrition outcomes in cervical esophageal cancer.

Masahiro Fuse, Hisashi Fujiwara, Taichi Ogo, Kenro Kawada, Keisuke Okuno, Toshiro Tanioka, Shigeo Haruki, Masanori Tokunaga, Yusuke Kinugasa

Abstract read
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In one paragraph

Article in Esophagus : official journal of the Japan Esophageal Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Masahiro FuseDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo, Tokyo, 113-8510, Japan.
Hisashi FujiwaraDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo, Tokyo, 113-8510, Japan. fujsrg1@tmd.ac.jp.ORCID 0000-0001-8909-8160
Taichi OgoDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo, Tokyo, 113-8510, Japan.
Kenro KawadaDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo, Tokyo, 113-8510, Japan.
Keisuke OkunoDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo, Tokyo, 113-8510, Japan.
Toshiro TaniokaDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo, Tokyo, 113-8510, Japan.
Shigeo HarukiDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo, Tokyo, 113-8510, Japan.
Masanori TokunagaDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo, Tokyo, 113-8510, Japan.
Yusuke KinugasaDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo, Tokyo, 113-8510, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCervical esophageal cancer surgery can lead to postoperative gastric issues, impairing nutritional quality of life. This study aimed to compare larynx-preserving cervical esophagectomy with free jejunal graft interposition and subtotal esophagectomy with gastric pull-up reconstruction in terms of both short-term and long-term outcomes, with a particular focus on short-term nutritional parameters.

methodsThis single-institution, retrospective study included 87 patients who underwent surgery for cervical esophageal cancer between January 2011 and December 2021. Patient characteristics and postoperative outcomes were analyzed to compare larynx-preserving cervical esophagectomy with free jejunal graft interposition (CE group, n = 26) and subtotal esophagectomy with gastric pull-up reconstruction (SE group, n = 61); furthermore, nutritional parameters were analyzed in patients from both groups who could be followed up for > 1 year postoperatively (nutritional CE group, n = 20; nutritional SE group, n = 41).

resultsDemographic differences between the CE and SE groups were not significant. The postoperative complication rates, length of hospital stay, and mortality rates were similar between the groups. Survival analysis showed no significant differences in 5-year overall survival (69.2% vs. 62.8%, p = 0.554) or recurrence-free survival (54.5% vs. 55.7%, p = 0.933) between the nutritional CE and SE groups. Changes in bodyweight and Onodera's prognostic nutritional index were less negative in the nutritional CE group (-0.4% vs. -15.2%, p < 0.001, and 0.68% vs. -2.68%, p = 0.028, respectively).

conclusionLarynx-preserving cervical esophagectomy with free jejunal graft interposition has a significant advantage in improving postoperative nutritional status without increasing complications or compromising long-term outcomes, compared to subtotal esophagectomy with gastric pull-up reconstruction. Therefore, it is a viable initial surgical option for patients with resectable cervical esophageal cancer who are candidates for radical resection with cervical esophagectomy alone.

Indexed as

Body WeightEsophageal NeoplasmsEsophagectomyNutritional StatusPostoperative ComplicationsAgedFemaleHumansJejunumMaleMiddle AgedOrgan Sparing TreatmentsPostoperative PeriodQuality of LifeRetrospective StudiesTreatment OutcomeCervical esophagectomyFree jejunal graft interpositionLarynx-preserving surgeryNutrition

Identifiers

PMID40892350

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.