Evidence map›Paper›PMID 40892316›Full record

Observational studyClinical oral investigations2025

Medication-Related osteonecrosis of the jaw involving dental implants: A 16-Year observational study in a single cancer center.

Raphael de Lima Chaparin, Yuri de Lima Medeiros, Rui Figueiredo, Graziella Chagas Jaguar, Rodrigo Nascimento Lopes, André Caroli Rocha, Fabio Abreu Alves

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Raphael de Lima ChaparinDepartment of Stomatology, A.C. Camargo Cancer Center, Rua Prof. Antônio Prudente, 211, Liberdade, São Paulo, 01509-900, SP, Brazil.
Yuri de Lima MedeirosDepartment of Stomatology, São Paulo University, São Paulo, SP, Brazil.
Rui FigueiredoFaculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.
Graziella Chagas JaguarDepartment of Stomatology, A.C. Camargo Cancer Center, Rua Prof. Antônio Prudente, 211, Liberdade, São Paulo, 01509-900, SP, Brazil.
Rodrigo Nascimento LopesDepartment of Stomatology, A.C. Camargo Cancer Center, Rua Prof. Antônio Prudente, 211, Liberdade, São Paulo, 01509-900, SP, Brazil.
André Caroli RochaDepartment of Stomatology, A.C. Camargo Cancer Center, Rua Prof. Antônio Prudente, 211, Liberdade, São Paulo, 01509-900, SP, Brazil.
Fabio Abreu AlvesDepartment of Stomatology, A.C. Camargo Cancer Center, Rua Prof. Antônio Prudente, 211, Liberdade, São Paulo, 01509-900, SP, Brazil. falves@accamargo.org.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to evaluate the clinicoradiological features and treatment approaches of MRONJ in cancer patients rehabilitated with osseointegrated implants. MATERIALS AND

methodsMedical records of 147 patients who developed MRONJ over a 16-year period were evaluated. Demographic data, type of antiresorptive medication (AR) used, route of administration, frequency, and time of use were collected. Staging, clinical and imaging characteristics, and treatment for MRONJ were also collected.

resultsA total of 25 patients (17%) presented with implants in the region affected by MRONJ, of whom 23 (92%) underwent implant placement prior to the initiation of AR. The total number of affected implants was 42 and most had an external hexagon connection (n = 25, 59.5%). Among these patients, 28 MRONJ areas were identified, most of which were classified as stage 2 (n = 17, 60.7%) and located in the posterior mandible (n = 16, 57.1%). Pain (n = 17, 68%) and the presence of osteolytic areas (n = 21, 84%) were the most commonly observed clinical and imaging characteristics. Surgical treatment was the preferred approach in 84% (n = 21) of cases.

conclusionsMRONJ involving implants occurred mainly in patients rehabilitated before AR, with frequent involvement of the posterior mandible, pain, and osteolytic areas on radiological imaging. Surgical intervention showed a high rate of clinical success. CLINICAL RELEVANCE: Implants placed prior to AR may act as local risk factors for MRONJ in cancer patients, underscoring the need for careful evaluation of existing implants before starting treatment.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsDental ImplantsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesBone Density Conservation AgentsDental ImplantsDental implantsMedication-related osteonecrosis of the jawPeri-implantitis

Identifiers

PMID40892316

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.